肠复康结肠定位滴丸的制剂研究及体内外评价-中药药剂学专业论文.docx

constancy of ChangfuKang colon delivery coating dripping pills. Coating the oil-components as coating pills, in the artwork research of dripping pills, apply mon- factor investigation to find out the kind of base material、the ratio of base material and medicine、the temperature of dosage liquor、the kind of condensing agent、the temperature of condensing agent、the dripping distance and speed etc. Further more, chose larger influence factors and better indexes as research levels to decide the forming artwork of dripping pills with orthogonal experiment. Apply PH-enzyme relying association leechdom mechanism and multi-coating technology, using vitro-releasing degree method as evaluation, settle the coating artwork of dripping pills. Observing the dripping pills under sweep electron microscope, research the dispelling mechanism of medicine, and the experiment shows that the dispelling of the dripping pills is identical with the design. In the research of vitro-dispelling degrees of praeparatum, build the technology investigation of control article of 2-aminopropionic acid of content assay method in artificial gastric juice、artificial intestinal juice and zymo- intestinal juice. Investigate affecting factors of vitro-dispelling, such as the assay method and turning speed, the results indicate that the dispelling curving of multi-coating dripping pills is the most suitable design for colon delivery of drugs, because it won’t dispel in stomach and almost won’t leak out in small intestine(61%), therefore, it dispels totally within 2 hours in zymo- intestinal juice. Using ? － ray scintigraphy and X ray Baso4 visualization to study the dispelling proceeding of multi- coating dripping pills in dogs and human bodies. The results show that the multi- coating dripping pills has excellent locating disposition of colon in body. Building Rbt-dextran free drinking model, using the damage of colon shape、 histological anatomy and MPO of heterophil granulocyte，research the cur