copd的定义、发病机制跟诊断.pptVIP

一、定义、 流行病学和危险因素 COPD的患病率－中国COPD流行病学研究 COPD的死亡率－COPD是中国主要致死性疾病 (2000年） 正常人的肺泡排空 COPD患者的肺泡排空 正常人的呼吸 COPD患者的呼吸 COPD患者气道平滑肌增厚 The animation begins with the alveolus fully inflated. Over the course of a normal exhalation, the alveolus fully deflates. With inhalation, the alveolus re-inflates. In COPD, irreversible damage causes the alveolar walls and supports to lose elasticity compared with the normal condition. The airways are partly collapsed and occluded, an effect made worse by reversible cholinergic constriction.1 As a result, deflation is slower, and so the alveolus only partly deflates