2011—2017年南京市第一医院治疗脑梗死中药注射剂的不良.PDFVIP

·2446 · 现代药物与临床 Drugs Clinic 第 33 卷 第 9 期 2018 年 9 月 2011—2017 年南京市第一医院治疗脑梗死中药注射剂的不良反应分析 1, 2 2 黄巧玲 ，潘希丁 1. 中国药科大学，江苏 南京 211198 2. 南京医科大学附属南京医院（南京市第一医院），江苏 南京 210006 摘 要：目的 分析南京市第一医院神经内科脑梗死患者使用中药注射剂的不良反应发生规律及特点，为中药注射剂的合理 使用提供参考依据。方法 采用回顾性分析方法，筛选符合要求的不良反应报告，记录相关信息，结合指南和文献进行分析。 结果 符合要求的报告有 204 份，不良反应发生特点为涉及药品共有 12 种，分为 3 大类，其中活血化瘀类占比最大（85.5% ）； 有 51.5%存在药品联用情况；男性居多（61.8% ），高峰年龄段为 60～70 岁（25.0% ）；不良反应多在用药第 1 天（72.1% ） 出现；皮肤及其附件损害最多（29.6% ），其次为神经系统损害（23.5% ）和心血管系统损害（13.6%）。结论 应加强中药注 射剂不良反应监测工作，促进临床安全用药。 关键词：中药注射剂；脑梗死；不良反应；合理用药 中图分类号：R913 文献标志码：A 文章编号：1674 - 5515(2018)09 - 2446 - 05 DOI: 10.7501/j.issn.1674-5515.2018.09.063 Analysis on adverse reactions of traditional Chinese medicine injection in treatment of cerebral infarction in Nanjing First Hospital from 2011 to 2017 HUANG Qiao-ling1, 2, PAN Xi-ding2 1. China Pharmaceutical University, Nanjing 211198, China 2. Department of Pharmacy, the Affiliated Nanjing Hospital of Nanjing Medical University (Nanjing First Hospital), Nanjing 210006, China Abstract: Objective To analyze the laws and characteristics of the Adverse Drug Reaction (ADR) of traditional Chinese medicine injection in treatment of cerebral infarction in Nanjing First Hospital, and to provide a reference for rational drug use of traditional Chinese medicine injection. Methods A retrospective study was conducted on the ADR reports. The related information was recorded. Then the data according to related guidelines and documents were analyzed. Results A total of 204 ADR reports were included according to inclusion criteria. There were 12 kinds of traditional Chinese medicine injections that could be divided into three categories, and the blood-activating and stasis-resolving type made up the largest percentage (85.5%) of the injections. There were 51.5% reports of dr