烟酰胺腺嘌呤二核苷酸-上海有机化学研究所.PDF

DOI: 10.6023/cjoc201508010 综述与进展 有机化学 Chinese Journal of Organic Chemistry REVIEW ＋ ＋ 烟酰胺腺嘌呤二核苷酸(NAD )类似物的合成及与NAD 依赖型酶 相互作用进展 侯淑华* 曲忠国 钟克利 边延江 汤立军 (渤海大学化学化工学院 辽宁省功能化合物的合成与应用重点实验室 锦州 121013) 摘要 烟酰胺腺嘌呤二核苷酸(NAD＋)与 NAD＋依赖型酶间的相互作用在细胞氧化还原反应、能量代谢、信号转导过程 中发挥着重要作用. NAD＋依赖型酶利用共同的辅酶, 它们之间相互作用规律受到越来越广泛的关注. 主要针对 NAD ＋ 类似物的合成及与 NAD＋依赖型酶相互作用研究的最新进展作一综述, 包括 NAD＋类似物的合成及其与天然 NAD＋依 赖型酶相互作用、NAD＋与突变酶相互作用及 NAD＋类似物与突变酶相互作用. 关键词 NAD＋ ＋ ＋ ; NAD 类似物; NAD 依赖型酶; 相互作用 ＋ Recent Advances in Nicotinamide Adenine Dinucluotide (NAD ) Analogs Synthesis and Their Interactions with ＋ NAD -Dependent Enzymes Hou, Shuhua* Qu, Zhongguo Zhong, Keli Bian, Yanjiang Tang, Lijun (Liaoning Key Laboratory for the Synthesis and Application of Functional Compounds, Department of Chemistry, Bohai University, Jinzhou 121013) Abstract Interactions between nicotiamide adenine dinucleotide (NAD＋) and NAD＋-dependent enzyme play a crucial role in cellular redox state, energy metabolism, catabolism , anabolism and signal transduction. The rules of interaction between NAD ＋ and NAD＋-dependent enzyme have attracted increasing attention due to so many cellular processes are connected to NAD＋. This review highlights some recent progresses in the fields of NAD＋ analogs synthesis and interactions with NAD＋- depend- ent enzyme includ