纳布啡的药理学和临床应用进展.pdfVIP

Advances in Clinical Medicine 临床医学进展, 2018, 8(3), 289-294 Published Online May 2018 in Hans. /journal/acm /10.12677/acm.2018.83049 Advance in Research on the Pharmacology and Clinical Use of Nalbuphine Changmao Zhu, Cong Wang, Xianwei Zhang Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Hubei st th th Received: Apr. 21 , 2018; accepted: May 10 , 2018; published: May 17 , 2018 Abstract Nalbuphine is a synthetic opioid agonist-antagonist analgesic derivative of the phenanthrene group, and its structure is C H NO , similar to those of naloxone and oxymorphone. It acts as a 21 27 4 mu-opioid receptor antagonist and kappa-opioid receptor agonist, with analgesic potency equiva- lent to morphine and better safety profile. Nalbuphine is mainly used to treat and prevent mod- erate to severe pain. Keywords Nalbuphine, Pharmacology, Clinical Use 纳布啡的药理学和临床应用进展 朱昌茂，王 聪，张咸伟 华中科技大学同济医学院附属同济医院麻醉科，湖北 武汉 收稿日期：2018年4月21 日；录用日期：2018年5月10 日；发布日期：2018年5月17 日 摘 要 纳布啡是一种吗啡喃类半合成激动–拮抗镇痛药，分子式C H NO ，结构上类似于阿片受体拮抗剂纳 21 27 4 洛酮和强效阿片类镇痛药羟吗啡酮，主要通过激动κ受体、拮抗μ受体发挥药理作用。镇痛效价与吗啡类 似，但副作用较少，安全性较高，主要应用于中重度疼痛的治疗。 文章引用: 朱昌茂, 王聪, 张咸伟. 纳布啡的药理学和临床应用进展[J]. 临床医学进展, 2018, 8(3): 289-294. DOI: 10.12677/acm.2018.83049 朱昌茂 等 关键词 纳布啡，药理学，临床应用 Copyright © 2018 by authors and Hans Publishers Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). /licenses/by/4.0/ Open Access 1. 引言 纳布啡是一种吗啡喃类半合成激动–拮抗镇痛药，分子式 C H