磷酸肌酸治疗急性脑梗死临床的研究.docVIP

磷酸肌酸治疗急性脑梗死临床的研究 　　[摘要] 目的 探究磷酸肌酸注射液治疗急性脑梗死的临床疗效。方法 选择急性脑梗死患者100例，随机分为磷酸肌酸治疗组50例及对照组50例。对照组采用常规治疗，给予血栓通注射液0.3 g，每日1次静脉滴注，硫酸氢氯吡格雷片75 mg，每日1次口服，疗程为15 d。治疗组在常规治疗基础上加用磷酸肌酸注射液1.0 g，每日2次静脉滴注，疗程15 d。结果 治疗组神经功能缺损评分积分明显下降，与对照组比较差异有统计学意义（P ＜ 0.01），脑梗死体积减少程度与对照组比较，差异有统计学意义（P ＜ 0.05）。结论 磷酸肌酸注射液对急性脑梗死的治疗有辅助作用，能降低致残率，改善急性脑梗死患者的预后。 　　[关键词] 急性脑梗死；治疗；磷酸肌酸；疗效 　　[中图分类号] R743.33 [文献标识码] A [文章编号] 1674-4721（2012）03（c）-0027-03 　　 　　Clinical study of creatine phosphate in acute cerebral infarction treatment 　　WU Guo 　　CITIC Heavy Machinery Company Staff Hospital in Henan Province, Luoyang 471003, China 　　[Abstract] Objective To evaluate the clinical effect of creatine phosphate injection in acute cerebral infarction. Methods One hundred patients of acute cerebral infarction were randomized into treatment group and control group(50 patients in each). The control group was underwent extract of Zhusheyong Xueshuantong 0.3 g intravenously per day, and clopidogrel bisulfate tablets 75 mg orally per day for 15 days. And, the treatment group was treated with creatine phosphate injection 1.0 g intravenously twice a day for 15 days besides the drugs. Results Neurologic impaired function score in treatment group were decreased apparently, and there was statistical difference compared to control group ?P ＜ 0.01?. There were apparent statistical differences between two groups in cerebral infarction volume?P ＜ 0.05?. Conclusion Creatine phosphate injection has assistant effect on treatment of acute cerebral infarction, which can decrease disability rate and improve prognosis. 　　[Key words] Acute cerebral infarction; Treatment ;Creatine phosphate; Effect 　　 　　脑梗死是指各种原因所致的脑部血液供应障碍，导致脑组织缺血、缺氧性坏死，出现相应神经功能缺损。急性脑梗死在临床上为常见病、多发病，是目前导致人类死亡的三大主要疾病之一，并且存活者中50%~70%患者遗留有严重残病[1]，欧洲治疗指南指出对急性脑梗死目前无特效神经保护剂，而磷酸肌酸在本院急性脑梗死的治疗过程中起到了一定疗效。现报道如下： 　　1资料与方法 　　1.1一般资料 　　选择2008年1月~2011年6月在本科住院的急性脑梗死患者100例，均符合第四届脑部血管病会议制定的急性脑梗死的诊断标准[2]，并经头部CT或MRI检查证实。入选患者按随机原则分为磷酸肌酸治疗组和对照组各50例。两组患者的年龄、性别、体重及神经功能缺损评分比较差异均无统计学意义。见表1。