脑灌注成像原及其应用.pptVIP

常规MRI一般根据肿瘤的强化程度等指标进行术前分级，但胶质瘤作为脑内肿瘤，其强化程度取决于BBB的破坏程度，及肿瘤细胞外间隙大小和肿瘤血供。 多项研究表明高级别胶质瘤血管生成明显，较低级别胶质瘤表现更高的CBV。 例1 a b c FLAIR image (a),contrast-enhanced axial T1-weighted image (b), and CBV map (c) from a patient affected by glioma grade IV. In the CBV map (c) warmer colors indicate higher CBV values suggesting higher perfusion and neovascularization. Comparison of CBV map (c) and contrast-enhanced axial T1-weighted image highlights a mismatch area (surrounded by the circle) corresponding to the extension of the high perfusion area outside the contrast-enhancement: this indicates a more extensive