实时超声弹性成像技术在大鼠梗阻性黄疸模型定量诊断中的价值.docVIP

实时超声弹性成像技术在大鼠梗阻性黄疸模型定量诊断中的价值 ［ ］目的探?实时超声弹性成像技术（RTE） 的弥散定量分析功能对大鼠梗阻性黄疸模型肝脏改变 的定量化诊断价值。方法选取30只2.5?3.0个月龄， 体质量280?330 g的雄性SD大鼠，随机分为甲组（实 验组）与乙组（对照组），每组15只。甲组大鼠行手 术制作可复性梗阻性黄疸动物模型，乙组大鼠仅行假 手术。分别于造模前、造模后2周及解除梗阻后2周 采用带有组织弥散定量分析软件的超声诊断仪对动物 模型进行RTE检查，并对弹性图像进行弥散定量分析; 比较分析造模前、造模后2周、解除梗阻后2周两组 大鼠％AREA和MEAN值的变化情况。结果造模前及 解除梗阻后2周时两组大鼠值及MEAN值比 较，差异均无统计学意义（P0.05）；甲组大鼠造模后 2 周％AREA 及 MEAN 值分别为 42.60±3.69、93.20土 2.54，与乙组的 25.40±1.40、108.00±4.93 比较，差 异有统计学意义（t=6.230、4.328，P=0.019、0.047）； 甲组大鼠造模后2周时％AREA和MEAN值分别与造模 前及解除梗黄后2周比较，差异均有统计学意义（P ［关键词］超声弹性成像技术；梗阻性黄疸；应变 均值；蓝色领域百分比 ［ ］R655.8 ［ ］A ［ ］ 1674-4721 (2017) 04 (a) -0008-04 Quantitative diagnostic value of real-time ultrasound elastography in rats with obstructive jaundice MENG Yel XIAO Yang2 LIU Yong3 WANG Tao4 XI Ke-min4 1.Department of Ultrasound，the Second Affiliated Hospital of Mudanjiang Medical University, Heilongjiang Province，Mudanjiang 157009，China； 2.Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Mudanjiang Medical University, Heilongjiang Province, Mudanjiang 157009，China； 3.Mudanjiang Medical University，Heilongjiang Province，Mudanjiang 157011， China； 4.Department of Ultrasound, Hongqi Hospital of Mudanjiang Medical University, Heilongjiang Province, Mudanjiang 157011，China ［Abstract］Objective To explore the quantitative diagnostic value of RTE for quantitative analysis of the elasticity of the liver changes in rats with obstructive jaundice.Methods 30 male SD rats (2.5-3.0 months， 280-330 g) were randomly divided into group A (experimental group) and group B (control group), 15 rats in each group.Rats of the group A was operated to make refolding obstructive jaundice animal model， while group B was only given the sham operation.Ultrasound diagnostic imaging software was used to analyze the elasticity of the liver changes of the animal models preoperative，2 weeks after the modeling and 2 weeks after the removal of the obstruction； and the diffusion quantitative analysis of the elastic image, the percentag