润燥止痒胶囊联合氯雷他定治疗老年性瘙痒症的的疗效观察.docVIP

润燥止痒胶囊联合氯雷他定治疗老年性瘙痒症的的疗效观察 　　[摘要] 目的：探讨润燥止痒胶囊联合氯雷他定治疗老年性瘙痒症的疗效。方法：将162例患者随机分为两组，对照组80例，氯雷他定10 mg po，qd；治疗组82例，在对照组的基础上加服润燥止痒胶囊4粒，po，tid，两组均连续治疗4周，结果：治疗组有效率为85.37%，对照组为57.50%，两组比较，有显著性差异（P＜0.01）。两组患者在瘙痒缓解起效时间、瘙痒程度、发生频率、瘙痒持续时间、继发皮损等方面比较，均有显著性差异（均P＜0.01），在瘙痒消失时间方面比较，无显著性差异（P＞0.05）。结论：润燥止痒胶囊联合氯雷他定治疗老年性瘙痒症疗效明显。 　　[关键词] 润燥止痒胶囊；氯雷他定；老年性瘙痒症 　　[中图分类号] R758.31[文献标识码]B [文章编号]1673-7210（2010）10（a）-057－０2 　　 　　The efficacy observation of Runzao Zhiyang Capsule combined with Loratadine in treatment of patients with pruritus senilis 　　FAN Miaoling, DENG Wenquan, LI Kelun 　　(Chronic Disease Hospital of Meizhou City, Guangdong Province, Meizhou 514021, China) 　　[Abstract] Objective: To explore the efficacy of Runzao Zhiyang Capsule combined with Loratadine in treatment of patients with pruritus senilis. Methods: 162 patients were divided into two groups at random, 80 patients in the control group and 82 patients in the treatment group. The control group, taking orally Loratadine, 10 mg po, qd. The treatment group, taking orally Loratadine, 10 mg po, qd, additionally, taking orally Runzao Zhiyang Capsule, 4 capsules each time po, tid. All patients in two groups were treated continuously for 4 weeks. Results: The effective rate of the medicine used in the treatment group was 85.37%, and the rate in the control group was 57.50%, there was a significant difference in two groups (P0.05). Conclusion: There is a significant curative efficacy that Runzao Zhiyang Capsule together with Loratadine in the treatment of pruritus senilis. 　　[Key words] Runzao Zhiyang Capsule; Loratadine; Pruritus senilis 　　 　　老年性瘙痒症是皮肤科一种常见病，多由于皮脂腺功能减退、退行性萎缩等因素引起，以秋、冬季多见，表现为皮肤干燥、瘙痒。病情呈阵发性加重，因搔抓出现抓痕、血痂、色素沉着和苔藓样变等继发性损害，常影响睡眠而导致情绪烦躁不安，给患者带来极大的痛苦和烦恼。目前临床上主要采用口服抗组胺药及镇静催眠剂等对症治疗的方法，但疗效较差。中医治疗老年性瘙痒症主要采取养血祛风、润燥止痒的治本方法。本文中笔者于2008年1月～2009年11月采用润燥止痒胶囊联合氯雷他定治疗老年性瘙痒症，疗效明显，现报道如下： 　　1 资料与方法 　　1.1 一般资料 　　162例患者均来自我院皮肤科门诊，符合老年性瘙痒症诊断[1]，中医辨证为血虚风燥者：好发于冬、春季，皮肤干燥脱屑、瘙痒明显，可伴有抓痕及血痂等继发皮损，舌质淡、苔薄白，脉弦缓或弦滑[2]。其中，男101例，女61例；年龄60～8