泮托拉唑治疗反流性食管炎的的疗效观察.docVIP

泮托拉唑治疗反流性食管炎的的疗效观察 　　[摘要] 目的：评价并与奥美拉唑比较泮托拉唑治疗反流性食管炎的疗效和安全性。方法：60例胃镜诊断的反流性食管炎患者，随机分为2组，每天分别口服泮托拉唑胶囊40 mg和奥美拉唑肠溶片40 mg，于治疗4周和8周后观察反酸、烧心、反食等症状的改善情况，并复查胃镜，观察镜下治愈率，详细记录不良反应。结果：治疗4周后，两组症状明显改善，症状记分较治疗前明显下降(P0.05)；泮托拉唑组治愈率分别为60.0% 、83.3%，奥美拉唑组为53.3%、76.7%，两组比较无显著性差异(P0.05)。两组患者均能良好耐受，末发现严重的不良反应。不良反应率泮托拉唑组为3.3%，奥美拉唑组为6.7% ，两组比较无显著性差异(P0.05)。结论：泮托拉唑是治疗反流性食管炎安全、有效的药物。 　　[关键词] 胃食管反流病；反流性食管炎；泮托拉唑；药物治疗 　　[中图分类号]R571[文献标识码]A [文章编号]1673-7210（2007）08（a）-042-02 　　 　　The effects of pantoprazole in patients with reflux esophagitis 　　CHEN Qi-ming, LONG Jie-wen, YANG Zhi-fen 　　(The Second People’s Hospital of Zhaoqing , Zhaoqing 526060,China ) 　　[Abstract] objective：To compare the efficacy and safety of pantoprazolewith that of omeprazolein patients with reflux esophagitis disease. Methods：60 patients with endoscopically confirmed reflux esophagitis were enrolled. They were randomly divided into two groups. 30 patients were treated with a once-daily dose ofpantoprazole 40 mg in the treatment groups. 30 patients were treated with a once-daily dose ofomeprazole 40 mg in the control group, and reflux symptoms including regurgitation, heartburn and food reflux were evaluated after 4 and 8 weeks. And endoscopy was performed to study the healing rate. Results：After 4 weeks treatment ，the symptoms improved significantly, and symptom scores were greatly decreased in both groups(P0.05). The healing rate was 60.0%，83.3% after 4，8 weeks in the treatment group, and 53.3%，76.7% in the control group.There was no difference between two groups(P0.05),The rate of side effects were 3.3% in the treatment group, 6.7% in the control group.There was no difference between two groups(P0.05). Conclusion：Pantoprazole is an effective and safe drug for reflux esophagitis. 　　[Key words] Gastroesophageal reflux disease；Reflux esophagitis；Pantoprazole；Drug therapy 　　 　　胃食管反流疾病是消化系统常见病。反流性食管炎有效的治疗是减少胃酸分泌，泮托拉唑作为新一代质子泵阻滞剂，在治疗酸相关性消化系统疾病方面有良好的疗效[1]。2001年11月~2003年11月，本院应用泮托拉唑治疗30例反流性食管炎患者，并用奥米拉唑治疗30例作为对照组，现疗效报告如