肾病综合征患者血清CA125临床意义的研究.docVIP

肾病综合征患者血清CA125临床意义的研究 　　摘要：目的 探讨肾病综合征患者血清CA125的临床意义。方法 回顾性分析我院 2015年1月1日～2016年12月31日收治的原发性肾病综合征患者128例，以血清白蛋白水平、有无浆膜腔积液、治疗前后进行分组，比较各组间血清CA125变化情况。结果 肾病综合征患者中血清CA125阳性率为46.09%，正常对照组中血清CA125阳性率为3.39%，肾病综合征患者血清CA125阳性率比正常对照组高，具有显著统计学差异（P0.001）；A组患者的血清CA125水平为（163.2±73.4）U/ml，B组患者的血清CA125水平为（58.1±26.2）U/ml，A组血清CA125水平较B组水平高，具有显著统计学差异（P0.001）；A组患者血清CA125水平为（167.2±71.3）U/ml，B组患者血清CA125水平为（48.1±16.2）U/ml，A组血清CA125水平较B组高，具有显著统计学差异（P0.001）；血清白蛋白治疗前（21.3±6.7）g/L，血清CA125（128.5±76.4）U/ml，经过规范治疗12 w后复查相关指标，血清白蛋白水平较前升高（36.8±7.4）g/L，CA125水平较前下降（38.7±17.9）U/ml。结论 原发性肾病综合征患者血清CA125升高，其升高机制可能与低蛋白血症、浆膜腔积液等因素有关。 　　关键词：原发性肾病综合征；血清CA125；低蛋白血症；浆膜腔积液 　　中图分类号：R446.1 文献标识码：A 文章编号：1006-1959（2017）25-0031-03 　　Abstract：Objective To investigate the clinical significance of serum CA125 in patients with nephrotic syndrome.Methods A retrospective analysis of our hospital from January 1，2015 to December 31，2016，128 cases of patients with primary nephrotic syndrome，serum albumin，with or without serous fluid，before and after treatment were grouped，the changes of serum CA125 between the groups were compared.Results The positive rate of serum CA125 in patients with nephrotic syndrome was 46.09%.The positive rate of serum CA125 in normal control group was 3.39%.The positive rate of serum CA125 in nephrotic syndrome patients higher than in the normal control group，the difference was statistically significant （P0.001）；The level of serum CA125 in group A was（163.2±73.4）U/ml，the level of serum CA125 in group B was （58.1±26.2）U/ml，the level of serum CA125 in group A was higher than that in group B，with significant difference（P0.001）.The level of serum CA125 in group a was（167.2±71.3）U/ml，the level of serum CA125 in group b was （48.1±16.2）U/ml，the serum CA125 level of a group was higher than that in group B，the difference was statistically significant（P0.001）； serum albumin before treatment （21.3±6.7）g/L， serum CA125（128.5±76.4）U/ml，after review of relevant indicators standard after 12 w treatment， serum a