阿立哌唑合并碳酸锂治疗急性躁狂症对照的研究.docVIP

阿立哌唑合并碳酸锂治疗急性躁狂症对照的研究 　　【摘要】 目的 探讨阿立哌唑合并碳酸锂治疗急性躁狂症的疗效和安全性。方法 对急性躁狂症随机分为研究组和对照组，分别用阿立哌唑合并碳酸锂、氯 氮平合并碳酸锂治疗。以Bech-Rafaelsen躁狂量表(BRMS)评定疗效，以副作用量表(TESS)评 价安全性。结果 研究组治疗第1、2周末BRMS评分均明显低于对照组(P0.05)；研究组治疗后各时段TESS评分均低于对照组。结论阿立哌唑合并碳酸锂治疗急性躁狂症疗效好，安全性好，起效较慢。 　　【关键词】 阿立哌唑；氯氮平；碳酸锂；躁狂症 　　 　　A Comparative Study on Aripiprazole Combined with Lithium in the Treatment of Ac ute Mania. Huang Chengfan, Bai Caiyun. Guangxi Longquanshan Hospital, Li uzhou 545005, P.R.China 　　【Abstract】 Objective To compare the efficacy and safety of aripipraz ole combined with lithium in the treatment of acute mania. MethodsAll patients with ac ute mania were randomly into treatment group and control group, the treatment gr oup were given aripiprazole combined with lithium, control group were given cloz apine combined with lithium. The study lasted for 8 weeks. The efficacy and safe ty were evaluated with mania rating scale (MRMS) and treatment emergant symptomscale (TESS) respectively. Results The scones of MRMS ware signif icant lower th at of control group after 1 and 2 week, The scones of MRMS were no significant d ifferences between two groups after 4 and 8 week. The efficacy of treatmen t group after 8 week was similar to control group. The scones of TESS ware signi ficant lower that of control group after 1, 2, 4, 8week. Conclusion The efficacy of aripiprazole combined with lithium is good, and safety is hi gher in the treatment of acute mania, but it took effect more slowly. 　　【Key words】 Aripiprazole; Clozapine; Lithium; Mania 　　 　　有研究[1]发现，新型抗精神病药阿立哌唑与氯氮平治疗躁狂症的起效时间和疗效 相 当，也有人用阿立哌唑合并碳酸锂治疗躁狂症起效快、疗效好[2]。但是，在临床 工作中，我们 分别用阿立哌唑合并碳酸锂、氯氮平合并碳酸锂治疗急性躁狂症数例，发现起效时间和副作 用并不一致。为了更好地评估阿立哌唑合并碳酸锂治疗急性躁狂症的疗效和安全性，我们用 阿立哌唑合并碳酸锂治疗急性躁狂症，并与氯氮平合并碳酸锂治疗比较，现报道如下。 　　 　　1 对象和方法 　　 　　1.1 对象 为我院2005年6月～2007年I0月入院的患者，符合CCMD-3躁狂发作的诊断标准， Bech-Rafaelsen躁狂量表(BRMS)18分，年龄16岁～60岁，排除严重器质性疾病、药物过敏 史及孕妇、哺乳期妇女，入院前两周内未服用抗躁狂药和抗精神病药物。符合入组标准92例 ，随机分为研究组和对照组。 　　1.2 方法 ①治疗方法：两组均用碳酸锂治疗，起始量0.5/d，10天内加至治疗量1.0~1.75 g/d。研究组合用阿立哌唑合治疗，阿立哌唑的起始量为