阿尔茨海默病轻度认知障碍健康老人脑电图及神经心理学测试比较的研究.docVIP

阿尔茨海默病轻度认知障碍健康老人脑电图及神经心理学测试比较的研究 　　[摘要] 目的 比较阿尔茨海默病（AD）、轻度认知障碍（MCI）、健康老人脑电图（EEG）及神经心理学测试（MMSE）特点。 方法 选择2012年1月～2013年1月海军总医院海空勤体检中心进行检查的老年MCI患者115例为MCI组，选择同期AD患者共105例为AD组，健康体检老年人80名为对照组。三组均进行EEG检查和MMSE测试并比较检查结果。 结果 ①MCI组EEG总异常61例（53.0%），AD组EEG总异常98例（93.3%），对照组EEG总异常24例（30.0%），三组EEG总异常发生率比较，差异有高度统计学意义（χ2=87.87，P 0.05）。MCI组和AD组MMSE总分与对照组比较，差异均有统计学意义（P 0.05或P 0.01）。 结论 EEG检查并结合MMSE量表评价可对MCI患者做出较为准确的评价，是能够早期对MCI做出诊断的有效方法。 　　[关键词] 轻度认知障碍；阿尔茨海默病；脑电图；神经心理学测试 　　[中图分类号] R749.3 [文献标识码] A [文章编号] 1673-7210（2014）02（b）-0031-04 　　Comparative study of electroencephalogram， neuropsychological tests in patients with Alzheimer disease， mild cognitive impairment and elderly healthy people 　　YU Jian1 WANG Bing2 　　1.Department of Haikongqin Medical Center， Navy General Hospital， Liaoning Province， Dalian 100048， China； 2.Shandong Cancer Prevention and Control Institute， Shandong Province， Jinan 250117， China 　　[Abstract] Objective To compare the characteristics of electroencephalogram （EEG）， neuropsychological tests in elderly healthy people and patients with mild cognitive impairment （MCI）， Alzheimer disease （AD）. Methods 115 cases with MCI from January 2012 to January 2013 in Department of Haikongqin Medical Center， Navy General Hospital were selected as MCI group， 105 patients in the same term with AD were chosen as AD group， and 80 healthy elderly people were selected as control group. EEG and MMSE were used to test and the result was compared. Results ①61 cases （53.0%） with EEG total abnormity in MCI group， 98 cases （93.3%） with EEG total abnormity in AD group， 24 cases （30.0%） EEG total abnormity in control group were found； the difference of occurrence rate of EEG total abnormity in three groups was statistically significant （χ2=87.87， P 0.05）. The difference of total point between MCI group， AD group and control group was statistically significant （P 　　[Key words] Mild cognitive impairment； Alzheimer disease； Electroencephalogram； Neuropsychology test 　　阿尔茨海默病（AD）是常