低场核磁共振及成像技术剖析白芍炮制过程中水分变化规律.docVIP

低场核磁共振及成像技术剖析白芍炮制过程中水分变化规律 　　[摘要] 该文采用低场核磁共振（nuclear magnetic resonance，NMR）及成像（nuclear magnetic resonance imaging，MRI）技术对白芍炮制过程中的水分状态和含量进行研究，考察白芍药材水煮、干燥过程中驰豫时间（transverse relaxation time，T2）和MRI图像的变化。结果显示白芍鲜品中主要是自由水，煮制过程中，结合水的含量下降而自由水的含量增加，煮制过程结束时，白芍药材中自由水的含量达到90%以上。干燥过程中，T2向左移动，水分流动性降低。MRI图像显示白芍炮制过程中水分的增加和减少均是由外而内的过程，干燥结束时，剩余水主要存在于白芍内层。水分的变化对药材炮制后的品质和外观均有影响，低场核磁及成像技术为白芍药材炮制过程中水分的变化提供了直观的参考依据，研究结果为根类药材的炮制方法的优化及饮片评价提供直观的参考方法和技术支撑。 　　[关键词] 白芍；炮制；低场核磁共振技术；驰豫时间 　　[Abstract] Moisture status and content during the processing of Paeoniae Radix Alba were studied by nuclear magnetic resonance （NMR） and nuclear magnetic resonance imaging （MRI） to investigate the changes of transverse relaxation time （T2） and MRI images during boiling and drying processes of Paeoniae Radix Alba. The results showed that water in Paeoniae Radix Alba fresh products was major of free water，and in the boiling process，the content of free water increased whereas the content of bound water declined. At the end of boiling，content of free water reached over 90%. During the drying process，T2 moved to the left，and moisture mobility was reduced. The MRI image directly showed that moisture transfer was outside-in process for both increase and decrease. At the end of drying，remaining moisture was mainly present in inner layer of Paeoniae Radix Alba. Quality and appearance were affected by the change of moisture during processing process of medicinal herbs. NMR and MRI could provide direct reference evidence for its moisture changes，and the results of this study could provide direct references and technical support for optimization of processing process of root medicinal materials and evaluation of Chinese herbal pieces. 　　[Key words] Paeoniae Radix Alba；processing process；nuclear magnetic resonance；transverse relaxation time 　　白芍是毛茛科植物芍?Paeonia lactiflora Pall.的干燥根，苦、酸，微寒，归肝、脾经，具有养血调经，敛阴止汗，柔肝止痛，平抑肝阳的作用[1]。白芍的炮制工艺较为复杂，夏、秋二季采挖，洗净，除去头尾和细根，置沸水中煮后除去外皮或去皮后再煮，然后干燥。炮制品质量的优劣直接关系到药材临床治疗的效果，因此，近年来，人们越来越关注中药炮制的过程