哮喘―慢阻肺重叠综合征患者例临床特征剖析.docVIP

哮喘―慢阻肺重叠综合征患者例临床特征剖析 　　[摘要] 目的 分析哮喘-慢阻肺重叠综合征（ACOS）患者的临床特征。方法 方便选择厦门大学附属第一医院呼吸内科2015年7月―2017年7月接收的ACOS患者76例，另选择同期接收的哮喘患者80例、慢性阻塞性肺疾病（COPD）患者80例，对比3组患者病历资料。结果 ①一般情况：3组患者性别、年龄、BMI相近，ACOS组与COPD组外周血嗜酸性粒细胞百分比、与哮喘组总IgE升高率相近，均差异无统计学意义（P0.05）；ACOS组外周血嗜酸性粒细胞百分比低于哮喘组，总IgE升高比例高于COPD组，均差异有统计学意义（P0.05）。③吸入支气管扩张剂后FEV1变异率：ACOS组FEV1变异率高于COPD组，差异有统计学意义（P0.05）。结论 ACOS患者临床特征处于哮喘与COPD之间，与COPD更为接近。 　　[关键词] 哮喘-慢阻肺重叠综合征；临床特征；肺功能 　　[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2017）11（a）-0063-03 　　[Abstract] Objective To analyze the clinical features of 76 cases of patients with Asthma Chronic obstructive pulmonary overlap syndrome. Methods 76 cases of ACOS patients admitted and treated in our hospital from July 2015 to July 2017 were conveniently selected and 80 cases of asthma patients and 80 cases of COPD patients at the same period were selected and the medical records data of the three groups were compared. Results The gender， age and BMI in the three groups were similar， and the peripheral eosinophils in the ACOS group and COPD group was similar to the total IgE increase rate in the asthma group， and there were no obvious differences（P0.05）， and the percentage of peripheral eosinophils in the ACOS group was lower than that in the asthma group， and the total IgE increase ratio was higher than that in the COPD group， and the difference was obvious（P0.05）， and the FEV1 mutation rate after inhalation of bronchodilator in the ACOS group was higher than that in the COPD group， and the difference was obvious（P0.05）. Conclusion The clinical feature of ACOS patients is between the asthma and COPD， and it is more similar to COPD. 　　[Key words] Asthma-chronic obstructive Pulmonary overlap syndrome； Clinical features； Lung function 　　哮喘与慢性阻塞性肺疾病（COPD）均属于临床中常见的呼吸系统疾病，尽管疾病类型不同，但临床上发现这两种疾病并存的患者不少，当患者并存哮喘与COPD时，称之为哮喘-慢阻肺重叠综合征（Asthma-COPD overlap syndrome，ACOS）[1]。ACOS虽是临床中常见疾病，但目前关于ACOS病因、病理生理、临床表现以及治疗等研究较少[1]。因此，该研究以该院2015年7月―2017年7月间接收的哮喘-慢阻肺重叠综合征患者为研究对象，分析其临床特征，为认知深入及治疗方案的合理制定提供参考。 　　1 资料与方法 　　1