复方黄连膏中雄黄的质量控制-中国中医药信息杂志.PDFVIP

·68· Chinese Journal of Information on TCM Mar.2018 Vol.25 No.3 论著 ·中药研究与开发 复方黄连膏中雄黄的质量控制 1 2 3 1 1 1 1 曾祖平 ，李彧 ，谭征 ，韩旭阳 ，彭冰 ，王宏 ，何薇 1.首都医科大学附属北京中医医院，北京市中医研究所，银屑病中医临床基础研究北京市重点实验室，北京 100010； 2.天津医科大学临床医学院，天津 300270 ；3.北京首儿药厂，北京 101304 摘要：目的 控制复方黄连膏中雄黄的质量。方法 对雄黄中毒性成分三氧化二砷采用古蔡氏法进行限度 检查；对雄黄主要成分二硫化二砷利用硫酸钾、硫酸铵和硫酸消解后采用滴定法进行定量分析。结果 复方黄 连膏中可溶性砷含量不高于 15.6 μg/g，二硫化二砷含量不低于2.21 mg/g 。结论 本方法简便易行，可以有效 控制制剂中雄黄的质量。 关键词：复方黄连膏；雄黄；三氧化二砷；二硫化二砷 DOI：10.3969/j.issn.1005-5304.2018.03.015 中图分类号：R284.1 文献标识码：A 文章编号：1005-5304(2018)03-0068-04 Quality Control of Realgar in Compound Huanglian Ointment 1,2 2 3 1 1 1 1 ZENG Zu-ping , LI Yu , TAN Zheng , HAN Xu-yang , PENG Bing , WANG Hong , HE Wei 1. Beijing Hospital of TCM Affiliated to Capital Medical University, Beijing Institute of TCM; Beijing Key Laboratory of Clinic and Basic Research with Traditional Chinese Medicine on Psoriasis, Beijing 100010, China; 2. Clinical Medical College of Tianjin Medical University, Tianjin 300270, China; 3. Beijing Shouer Pharmaceutical Factory, Beijing 101304, China Abstract: Objective To control the quality of realgar in compound Huanglian Ointment. Methods As O which 2 3 is the toxic component of realgar was carried limit test by Gutzeits test; Potassium sulfate, ammonium sulfate and sulfuric acid were used to digest, and then titration method was used to determine the content of As S in compound