毕业论文-1,4-环己二甲醇的合成研究论文.doc

长春工业大学论文 摘 要 1.4-环己二醇是重要的医药中间体和新材料单体：它是抗癌药、ＨＭＧＣOＡ还原酶、ＧpⅡb/Ⅲa拮抗剂、肌醇磷酸酯抑制剂、琥珀酰磺胺噻唑、苯并三唑类药物的重要中间体。光谱纯的1.4-环己二醇还是合成新材料如：液晶材料、有机电材料、生物控制器标识物等关键原料之一。　 本研究拟采用对苯二酚为原料，研究在超临界二氧化碳溶剂中反应，考察催化剂，温度，压力对反应的影响，以期获得高选择性的反式1，4-环己二醇的转化率。目前国内无该产品生产，特别是高纯的顺式和反式1.4-环己二醇生产和光谱纯1.4-环己二醇的年需求量均在数千吨。 本研究以超临界CO2中对苯二酚催化加氢制备1，4环己二醇为目标反应，考察了反应条件如温度、时间、压力等对转化率的影响。研究表明：反应介质对反应转化率的影响很大。在超临界CO2介质中，随着反应温度的升高，时间的延长，反应的转化率增大。反应的转化率受CO2压力、H2压力影响也较大。在超临界CO2介质中Ru/C催化剂催化作用下，对苯二酚在H2压力为2MPa，反应温度为180℃，反应时间为4小时，反应物的转化率达到了99.4%，目标产物1.4-环己二醇的选择性达到80.7％ 　　关键词：对苯二酚 加氢 环己二醇 二氧化碳 1.4-环己二醇 Abstact 1.4-cyclohexanediol is an important pharmaceutical intermediates and new materials monomers: it is anti-cancer drug, HMGCOA reductase, Gp Ⅱ b / Ⅲ a antagonists, inhibitors of inositol phosphate, succinyl-sulfathiazole, benzo c azole drugs, an important intermediate. Spectra of pure 1.4-cyclohexanediol or synthesis of new materials such as: liquid crystal materials, electroluminescent materials, biological marker, such as controllers, one of the key raw materials. In this study, to be used as raw materials of hydroquinone to study the supercritical carbon dioxide in the reaction solvent to study the catalyst, temperature, pressure on the reaction to obtain the high selectivity of trans-1,4 - cyclohexanediol. None of the current domestic production, especially the high purity of the cis-and trans-1.4-cyclohexanediol production and spectra of pure 1.4-cyclohexanediol in the annual demand of thousands of tons: the production process under mild conditions, the product good quality and high-string collection. In this study, supercritical CO2 in catalytic hydrogenation of hydroquinone 1,4 cyclohexanediol objective response of reaction conditions such as temperature, time, pressure on the impact of the conversion rate. Study shows that: the reaction medium on the reaction of a great influence on the conversion rate. In supercritical CO2 medium, with the reaction temperature, time of reaction increased the conversion ra