FLF4与5―FULV方案用于结直肠癌术后辅助化疗的远期疗效分析.docVIP

F0LF0X4与5-FULV方案用于结直肠癌术后辅助化疗的远期疗效分析 ［ ］目的探讨结直肠癌根治术后行 F0LF0X4与5-FU/LV辅助化疗方案的远期疗效。方法 选择四川省眉山市第二人民医院2011年12月?2014 年5月收治的63例结直肠癌根治术后患者为研究对象， 根据化疗方案的不同将其分为试验组30例和对照组 33例，其中对照组术后给予5-FU/LV辅助化疗，试验 组术后行FOLFOX4方案化疗，两组患者至少接受4个 周期的化疗方案。分析比较两组患者生存时间及化疗 不良反应。结果两组患者随访12?40个月，中位随 访时间为28.1个月。试验组中位生存时间为30.2个月， 对照组为22.3个月，两组患者中位生存时间经 Log-rank检验显示，试验组显著高于对照组(HR = 1.87， 95%CI： 1.06?3.64，P ［关键词］结直肠癌；辅助化疗；临床疗效；预后 ［ ］R735.35 ［ ］A ［ ］ 1673-7210 (2015) 08 (b) -0079-04 ［Abstract］ Objective To evaluate the long term efficacy of adjuvant chemotherapy regimens of F0LF0X4 and 5-FU/LV after radical resection for colorectal cancer. Methods 63 patients after radical resection for colorectal cancer admitted to the Second People’s Hospital of Meishan City from December 2011 to May 2014 were selected as research objects， and they were divided into experiment group (30 cases) and control group (33 cases) according to the difference of chemotherapy regimens. The patients in the control group were treated with 5-FU/LV adjuvant chemotherapy regimen after operation and patients in the experiment group were treated with F0LF0X4 chemotherapy regimen after operation. All of the enrolled patients received at least 4 cycles treatment regimen. The survival time and chemotherapy side effects were analyzed and compared between the two groups. Results The follow up period of the two groups was 12-40 months， with the median follow up period of 22.3 month. The median survival time was 30.2，22.3 months for the experiment group and control group respectively， the Log-rank test for the median survival time of the two groups showed that the experiment group was higher than control group (HR = 1.87， 95%CI： 1.06-3.64， P 1 资料与方法 1.1 一般资料 选取四川省眉山市第二人民医院普通外科2011 年12月?2014年5月收治的63例结直肠癌根治术后 患者作为研宄对象。纳入标准：有明确的病理学或细 胞学诊断；CT及腹部B超未发现远处转移；体力评分 0?2分者；既往否认化疗药物过敏史者；预计生存 期＞3个月。病例排除标准：头颅核磁共振成像显示多 发脑转移患者；合并其他恶性肿瘤者；严重肝肾功能 障碍者；严重心功能不全者；出凝血功能障碍者；获 得性免疫缺陷综合征者；孕产妇。本研宄通过医院医 学伦理委员会讨论同意实施。入组患者或监护人均签 署知情同意书，自愿加入该临床研宄。患者根据纳入 与排除标准入组后，根据化疗方案的不同将其分为对