强脉冲光联合胶原贴敷料治疗面部糖皮质激素依赖性皮炎疗效剖析.docVIP

强脉冲光联合胶原贴敷料治疗面部糖皮质激素依赖性皮炎疗效剖析 　　[摘要]目的：观察强脉冲光联合胶原贴敷料治疗面部糖皮质激素依赖性皮炎的疗效。方法：将入选的136例患者随机分为治疗组和对照组，两组均使用强脉冲光（Record-618，IPL）治疗，每3周治疗1次，6次为1个疗程，治疗组同时敷胶原贴敷料（澳宜）2～7次/周，一个疗程结束后评价疗效。结果：两组患者治疗效果比较，治疗组有效率（89.7%）高于对照组（75.0%），差异有统计学意义（P0.05），随访6个月治疗组无反复，耐受性好，无不良反应发生。结论：强脉冲光联合胶原贴敷料治疗面部糖皮质激素依赖性皮炎具有疗效好、无不良反应等优点。 　　[关键词]糖皮质激素依赖性皮炎；强脉冲光；胶原贴敷料；联合；疗效 　　[中图分类号]R758.22 [文献标志码]A [文章编号]1008-6455（2015）23-0044-04 　　Abstract： Objective To observe the efficacy of intense pulsed light combined with collagen dressing in treatment of facial hormone dependent dermatitis. Methods 136 patients selected were divided into treatment group and control group randomly.All patients in 2 groups were treated with intense pulsed light（Record-618，IPL），once three weeks.The treatment lasts for 6 therapeutic courses.At the same time，the patients of treatment group were given human-like collagen dressing（Aoyi），two-seven times a week.Treatment efficacy was evaluated after the end of one therapeutic course. Results There were significant statistical difference between two groups（P0.05）.Followed up for 6 months in treatment patients there were no relapse.There were well-tolerated and had no obvious adverse reaction. Conclusion There are advantages such as better effect and no adverse reaction intense pulsed light combined with human-like collagen dressing treating HDD. 　　Key words：hormone dependent dermatitis；intense pulsed light；collagen dressing；combined；treatment effective 　　近年来，随着糖皮质激素外用制剂的广泛应用和滥用，面部糖皮质激素依赖性皮炎的发病率不断上升，已成为皮肤科的常见病，由于皮肤对激素产生依赖[1]，一旦停用，皮肤就会出现戒断症状；同时激素的长期使用导致皮肤萎缩变薄，皮肤高敏感性，皮疹容易反复发作，严重影响患者容貌及身心健康。此病临床治疗方法较多，疗效差异较大。笔者科室于2012年3月-2014年9月应用强脉冲光联合胶原贴敷料治疗面部糖皮质激素依赖性皮炎患者，取得了满意疗效，报道如下。 　　1 资料和方法 　　1.1 一般资料 　　136例患者均符合面部糖皮质激素依赖性皮炎的诊断标准[2-3]，随机将其分为治疗组和对照组，每组各68例。治疗组：男4例，女64例，年龄18～55岁，病程3个月～5年；对照组：男3例，女65例，年龄17～58岁，病程3个月～5年。患者原发病多为面部皮炎、湿疹、痤疮及面部色素斑等，均曾有外用激素乳膏及美白祛斑性化妆品等药物史。入选标准：①外用含有糖皮质激素药物及化妆品1个月以上；②停药后原有疾病或皮损复发或加重，局部皮肤出现灼热、瘙痒、刺痛、干燥和紧绷感等主观症状，客观体征为：皮肤变薄、潮红伴毛细血管扩张，粉刺、丘疹脓疱等痤疮样皮损、色素沉着、毳毛增粗变长、皮肤脱屑萎缩等；③再次用药上述症状迅