TP和TGFβ1在特发性血小板减少性紫癜患者中的表达和意义.docVIP

TPO和TGF-M在特发性血小板减少性紫癜患者中的表达和意义 阿依姆妮萨bull;阿卜杜热合曼1努尔阿米娜bull;依明尼亚孜1刘加军2(通 讯 ) (1新疆喀什地区第一人民医院血液科新疆喀什844000) (2屮山大学血液病研究所510630) 】目的探讨特发性血小板减少性紫癜(idiopathic thrombocytopenic purpura ,ITP)患者血小板生成调控因子血小板生成素(Thrombopoietin,TPO｝和转化 生长因子beta;l (transforming growth factor -beta;l, TGF-beta;l)的变化并 探讨其临床意义。方法采用双抗体夹心酶联免疫吸附法(ELISA)检测30例ITP 和25例病例对照的TPO和TGF-beta;l的水平。25例健康体检者为正常对照组。 结果ITP患者血清TPO水平与正常对照组相比无显著性差异(Pgt;0.05)，病例 对照组TPO水平显著高于正常对照组(Plt;0.05)o ITP患者血清TGF-beta;l的 含量显著高于正常对照组(Plt;0.05)，病例对照组血淸TGF-beta;l的禽量与正 常对照组相比无显著性差异(Pgt;0.05),但显著低于ITP患者(Plt;0.05)。结 论检测ITP患者的TPO及TGF-beta;l水平对其发病机制研究、鉴别诊断方面 有重要价值。 关键词】特发性血小板减少性紫癜血小板生成素转化生长因子beta;l 屮图分类号】R554+.6 】A 】2095-1752 (2013) 13-0102-02 Levels of TPO and TGF-beta;l in patients with idiopathic thrombocytopenic purpura Ayimunisabull;Abudureheman，nueraminabull;yiminniyazi Department of Hematolog,the First Affiliated Hospital of Xinjiang Kashi； Xinjiang, Kashi 844000,China [Abstract] AIM: To explore the relationship between thrombopoietin(TPO),transforming growth factor-beta l(TGF-beta;l) and idiopathic thrombocytopenic purpura(ITP)o METHODS: ELISA was used to test the levels of TPO and TGF-beta;l in blood serum。RESULTS:The level of TPO in ITP patients was no difference with healthy donors (Pgt;0.05)，and levels of TPO in case control was significantly higher than that in healthy donors (Plt;0.05)。The level of TGF-beta;l in ITP patients was higher than healthy donors(Plt;0.05), and levels of TGF-beta;l in case control was significantly lower than that in ITP patients (Plt;0.05)， but showed no difference with healthy donors (Pgt;0.05)。CONCLUSION: The results indicate that detection of the serum levels of TPO and TGF-beta;l is of great value in the understanding of the pathogenesis,differential diagnosis of ITP o Keywords] idiopathic thrombocytopenic purpura thrombopoietin transforming growth factor -beta;l 特发性血小板减少性紫癜(ITP)是一种常见的免疫介导的血小板减少 综合征，以抗血小板自身抗体出现致血小板破坏，骨髓巨核细胞增多或正常，但 成熟障碍为特点。近年来,越来越多的研究证实,ITP的发生与骨髓巨核细胞的改变 关系密切，巨核细胞的增殖、分化、