TAL联合BP化疗在卵巢癌治疗中的安全性及有效性.docVIP

TAXOL联合CBP化疗在卵巢癌治疗中的 安全性及有效性 郎咸征 辽宁省阜新市第二人民医院（阜新市妇产医院） 目的探究紫杉醇（TAXOL）联合卡铂（CBP）治疗卵巢癌的有效性及安全性。方 法选取92例卵巢癌患者作为研宂对象，采用随机数字表法将患者分为2组，观 察组和对照组各46例。观察组采用TAXOL联合CBP进行治疗，对照组采用环磷 酰胺联合CBP治疗，21 d为1个疗程。采用世界卫生组织（WHO）实体瘤评价标 准对患者肿瘤缓解情况进行评定，对比2组患者药物不良反应以及随访5年内生 存率。结果观察组肿瘤治疗有效率（82.61%）明显高于对照组（58.70%） （P〈0.05）。2组患者在治疗中均出现中性粒细胞下降、血红蛋白下降、血小板 减少、白细胞减少、过敏反应、消化道反应、神经毒性等不良反应，治疗组发生 率低于对照组，但差异无统计学意义（P0. 05）。观察组5年内生存率（41.30%） 明显高于对照组（19.57%） （P〈0.05）。结论TAXOL联合CBP治疗卵巢癌，患者 肿瘤缓解情况较好、不R反应较轻，5年生存率较高。 关键词： 紫杉醇;卡铂;卵巢癌;临床疗效;安全性; 2016-12-23 Safety and Efficacy of TAXOL Combined with CBP Chemotherapy in the Treatment of Ovarian Cancer LANG Xianzheng The Second People’s Hospital of Fuxin; Abstract： Objective To investigate the efficacy and safety of paclitaxel (TAXOL) combined with carboplatin (CBP) in the treatment of ovarian cancer. Methods 92 cases of ovarian cancer were randomly divided into the observation group and the control group, with 46 cases in each group, the observation group was treated with TAXOL combined with CBP treatment, the control group received cyclophosphamide combined with CBP treatment, 21 d as a course of treatment, the WHO (WHO) evaluation criteria in solid tumors of patients with tumor remission were evaluated, adverse reactions and 5-year survival rates of the 2 groups were compared. Results The effective rate of the observation group (82. 61%) was significantly higher than that of the control group (58. 70%) (P 0. 05) ? Both groups had adverse reaction such as neutropenia, decreased hemoglobin, platelet less, leukopenia， allergic reactions, gastrointestinal reaction and neurotoxicity, the incidence of the treatment group was lower than that of the control group, but there had no significant difference (P 0. 05) . 5-year survival rate in the observation group (41. 30%) was higher than the control group (19. 57%) (P 0. 05) . Conclusion TAXOL combined with CBP chemotherapy is an effective for ovarian cancer, with good tumor remission, less adverse reactions and higher 5-