=主动脉夹层与高血压相关性因素研究.docVIP

邮编：200032 主动脉夹层与高血压相关性因素研究 沈洪1,2 姚志峰2 陆树洋2 赵维鹏 2薛渊1 姚晨玲1 魏来2王春生2 舒先红2 1复旦大学附属中山医院急诊科； 2上海市心血管病研究所 【摘要】目的 分析主动脉夹层与高血压相关因素为临床诊断提供指导。方法 回顾分析2003年1月至2008年6月复旦大学附属中山医院心外科住院主动脉夹层患者361例，对该组高血压病进行单因素或多因素Logistic回归分析。结果 高血压病占63.2%，单因素多因素分析Logistic回归分析结果：.单因素分析提示年龄（95%CI=2.775-6.585,OR=4.274,p=0.000)，病程(95%CI=.0.340-0.923,OR=4.274,P=0.023)，主动脉瓣膜中度以上反流(95%CI=0.198-0.680 ,OR=0.366 ,P=0.023以及转归(95%CI=0.235-0.942,OR=0.466,P=0.029)与高血压相关。多因素分析提示年龄（95%CI=0.235-0.942，OR=0.373，P=0.003）以及中度主动脉瓣膜反流CI=0.197-0.707，OR=0.373，P=0.003）与高血压相关。结论 主动脉瓣反流（中度）与高血压成负相关，有利于主动脉夹层的诊断。 【关键词】 主动脉夹层动脉瘤；高血压；危险因素 Factors of Relationships between the patients who suffered the aortic dissection and hypertension Shen Hong1,2，Yao Zhifeng2，Lu Shuyang2，Zhao Weipeng2，Xue Yuan1，Yao Chenling1，Wei Lai2，Wang Chunsheng2，Shu Xianhong2 1 Emergency Department of Zhongshan Hospital，Fudan University；2 Shanghai Institute of Cardiovascular Diseases 【Abstract】Objective To investigate the factors of relationship between the patients who suffered the aortic dissection and hypertension so as to diagnosis in Clinic. Methods The clinical data of 361 patients with aortic dissection from January 2003 to June 2008 were retrospectively reviewed. Nine variables were analyzed to identify the factors of relationships between the patients who suffered aortic dissection and hypertension by the analyses of univariate and multivariate logistic regression. Results The analysis of univariate logistic regression showed that age（95% CI=2.775-6.585,OR=4.274,P=0.000), Acute Course ( 95%CI=0.340-0.923, OR=4.274,P=0.023), moderate-to-severe aortic regurgitation(95%CI=0.198-0.680, OR=0.366, P=0.001), terminates fatally (95%CI=0.235-0.942, OR=0.466,P=0.029)were close relationships between the patients who suffered aortic dissection and hypertension. The multivariate analysis revealed that Age（95%CI=1.563-7.900，OR=3.514，P=0.002）and moderate-to-severe aortic regurgitation (95%CI=0.197-0.707，OR=0.373，P=0.003）significant independent factors of relations