《浙江大学医学免疫学经典课件免疫-白细胞分化抗原》课件.pptVIP

NK cells were defined initially by their ability to lyse certain tumor cell lines and virally infected cells without prior immunization,and so mediate a form of innate (or natural) immunity that is termed “natural killing”. NK cell (p140) Derive from a bone marrow precursor are large granular lymphocytes distribution: peripheral blood ,spleen Surface markers 1. CD56 2. CD16(FcγRⅢ) ADCC 3. FcR NK cells are generally TCR- , mIg-, CD16+, CD56+. The receptors associated with activation or inhibition 1.The receptors recognizing MHCⅠ molecules (1) Killer immunoglobulin-like recepto