注射用盐酸纳洛酮的制备及质量标准研究.pdfVIP

Chinese abstract．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．1 abstract…．……．．…．．．……．…．…．……．．…．…．．…．．……．．．……．．．…．………．．……．……．．…．．．．3 English Introduction…．……．……．．…．………．……．……．…．．…．．……．…．．…．．…．…………………．…．．…．．…．．6 1 Themedicinalcharacteristicsnaloxone ofdrug hydrochloride．．．．．．．．．．．．．．．．．．．．．．．．．．．6 1．1 and resrarch…．．．…．．．…．．…．………………．…．…．…．．6 Pharmacologytoxicology 2Naloxone synthesis process……．……．……．．……．．…．…．……．…………………．…．．……．．．8 2．1Naloxone ofdomesticandinternational synthesis background……………．8 2．2New route……………………………………………………………．9 processsynthesis 2．3A and reaction Deoxy study．．．．．．．．．．．．．．．．．．．．．．．．．．．．．10 methylationhydrolysis 2．4Lowconcentrationof acid methd………………………………．．10 hydrobromic 3Clinical 1 Study………………………………………………………………………………………．1 3．1Various ofshock…………………………………………………………………．11 types 3．2 Acuteischemicattackandcerebral infarction…．．……．……………．…．．…．．…11 3．3Subarachnoidandcerebral 1 hemorrhage hemorrhage…．…．．…………．．．…．．．1 3．4 cerebral resuscitation…………………………………………．．12 Cardiopulmonary 3．5 Neonatal hypoxic—ischemicencephalopathy……………………………………．12 3．6Pesticide sedative intoxicationandacutealcohotisml3 poisoninghypnotic 3．7Acute Pancreatitis…………………．…．……………