青年人食管癌患者生存风险因素COX剖析.docVIP

青年人食管癌患者生存风险因素COX剖析 　　[摘要] 目的：探讨青年人食管癌预后及生存相关的因素及风险因素。方法：选取我院收治的53例青年食管癌患者临床资料，采用单因素分析χ2检验及COX生存风险比例模型对患者预后与生存风险相关因素进行分析。结果：患者存活时间范围为10~142个月，中位生存时间32个月，1、3、5年生存率分别为92.4%、79.2%和30.2%，单因素分析显示，肿瘤直径、部位、TNM分期、分化程度、根治切除程度、放化疗与否是影响预后的相关因素，COX回归分析显示肿瘤TNM分期、肿瘤分化程度、根治切除与否是影响预后独立因素。结论：青年人食道癌的预后与肿瘤的生物学行为及治疗情况相关，适当的临床治疗能够改善青年食管癌患者的预后。 　　[关键词] 青年人食管癌；生存风险；相关因素；手术切除；肿瘤分期；预后 　　[中图分类号] R735.1 [文献标识码] A [文章编号] 1673-7210（2011）11（b）-020-03 　　 　　COX analysis of survival risk factor with prognosis on youth esophageal cancer 　　LIANG Xiang, ZOU Jihua, ZHOU Yiyong, GUAN Xin, LIANG Xi 　　Department of Chest Surgery, Shanghai Jiaotong University Affiliated Ninth People′s Hospital, Shanghai 200011, China 　　[Abstract] Objective: To investigate the survival risk and correlation factor with prognosis on youth esophageal carcinoma. Methods: 53 clinical dataes of young patients with esophageal carcinoma in our hospital were selected, survival risk and correlation factor were analyzed with univariate analysis Chi-square test and Coxapos analysis. Results: Live time of patients was from 10 monthes to 142 monthes, median survival time was 32 month in young patients with esophageal carcinoma, survival rate in a year, three years and five years was 92.4%, 79.2% and 30.2%. Univariate analysis shown that diameter of tumor, position of tumor, TNM stage of tumor, differentiation of tumor, heath or not be excision radical whether or not receive radiotherapy and chemotherapy were correlation factor with prognosis. Coxapos shown that TNM stage of tumor, differentiation of tumor, whether or not received radical excision were independent risk factors for prognosis. Conclusion: prognosis of patients with youth esophageal carcinoma is correlative with biological characteristics and treatment, suitable therapy can improve prognosis of patients with youth esophageal carcinoma. 　　[Key words] Youth esophageal cancer; Survival risk; Relation factor; Surgery; TNM stage of tumor; Prognosis 　　 　　 　　食管癌是消化道常见恶