超声造影实时动态观察猪结肠前哨淋巴结实验研究-影像医学与核医学专业论文.docxVIP

宁夏医科大学硕士研究生学位论文 宁夏医科大学硕士研究生学位论文 英文摘要 II II The experimental study of real-time imaging of the sentinel lymph nodes with CEUS in swine’s colon ABSTRACT Objective To observe the feasibility of CEUS (contrast -enhanced ultrasound with SonoVue) in detecting sentinel lymphatic node(SLN) of the colon in swine Methods SonoVue of different doses were injected into the serosa layer and sub-mucosal layers of the colon of 10 swines successively.CEUS was performed to observe changes of lymph vessels and SLN in real time.Then 1% Evans was injected at the same sites.The SLN detection rate and accuracy rate of CEUS were compared to those of conventional dyeguided method. Results The images of the afferent lymph vessel and SLN of the colon were clear after injecting 0.5ml and 1.0ml SonoVue.The internal structure of SLN and the flow of SonoVue microbubbles could be observed with CEUS.Compared with those of injecting 0.5ml SonoVue,the enhanced time of lymphatic and SLN as well asthe enhanced peaktime of SLN were obviously reduced after injecting 1.0ml SonoVue(all P0.05).SLN maintenance time between them had no statistical difference(P0.05).The SLN detection rate was 100% and accuracy rate was 95.65% (22/23)of CEUS,and compared with those of blue dye method,no statistical III III difference was found(P0.05). Conclusion The good imaging of SLN in swine＇s colon can be obtained with CEUS.CEUS may be used as a new effective detecting method of SLN and has potential clinical application value. KEYWORDS Contrast media，Ultrasonography，Animal experimentation， Sentinel lymphatic node 宁夏医科大学硕士研究生学位论文符号说明 宁夏医科大学硕士研究生学位论文 符号说明 PAGE PAGE IV 中英文缩略词表 英文缩写 英文名称 中文名称 SLN sentinel lymphatic node 前哨淋巴结 CEUS contrast-enhanced ultrasound with SonoVue 超声造影 CPS Contrast pulse sequencing， 对比对比脉冲序列 MI Mehanieal Index 机械指数 CDFI color doppler flow imaging 彩色多普勒血流成像 宁夏医科大学硕士研究生学位论文目录 宁夏医科大学硕士研究生学位论文 目录 目 录 HYPERLINK \l _bookmark0 前 言 1 HYPERLINK \l _bookmark1 材 料与方法 7 HYPERLINK \l _bookmark2 结 果