干燥综合征发病机制及口眼干燥治疗研究进展-中西医结合临床专业论文.docx

重庆医 重庆医科大学硕士研究生学位论文 万方数据 万方数据 英汉缩略语名词对照 英文缩写 英文全称 中文名称 BAFF B cell activating factor belonging to the TNF family B 细胞激活因子 BUT Tear break-up time 泪膜破裂时间 CTD Connective tissue disease 结缔组织病 CXCR3 Chemokine(C-X-C motif) receptor 3 趋化因子受体 EBV Epstein-Barr Virus EB 病毒 HIV Human immunodeficiency virus 人类免疫缺陷病毒 HLA Human leukocyte antigen 人白细胞抗原 IL-17 Interleukin 17 白细胞介素 IL-17 IFN-γ Interferon-γ γ 干扰素 MAPKs Mitogen-activated protein kinases 丝裂原活化蛋白激酶 OSDI Ocular surface disease 眼表疾病指数 PBMC Peripheral blood mononuclear cell 外周血单个核细胞 PDC Plasmacytoid dendritic cell 浆细胞样树突状细胞 pSS Primary Sjogrens syndrome 原发性干燥综合征 RF Rheumatoid factor 类风湿因子 RTX Rituximab 利妥昔单抗 SIt Schirmer I test 基础泪液分泌试验 SNP Single nucleotide polymorphism 单核苷酸多态性 SS Sjogrens syndrome 干燥综合征 Th17 T helper cell 17 辅助性 T 细胞 17 TLR Toll-like receptor Toll 样受体 TNF-α Tumor necrosis factor-α 肿瘤坏死因子 α 1 干燥综合征发病机制及口眼干燥治疗研究进展 摘 要 干燥综合征（SS）是一种外分泌腺功能障碍引起的全身性自身免 疫性疾病，其主要表现有口腔、眼、鼻、咽、喉和阴道表面粘膜的干 燥，由于泪腺和唾液腺是其外分泌腺中主要受累的腺体，故口干症及 眼干症是干燥综合征的主要临床表现。目前针对口眼干燥的临床治疗， 西医以促进外分泌腺体分泌和局部润滑保护为主，中医则主要以中药 内治及外治的方法，达到生津润燥，濡养孔窍的目的。本文对近年来 干燥综合征的发病机制及口眼干燥的中西医治疗研究进展综述如下。 关键词：干燥综合征；发病机制；口干症；干眼症；治疗 2 THE RESEARCH DEVELOPMENT OF SJOGRENS SYNDROME’S PATHOGENESIS AND THE TREATMENTS THAT ARE USED FOR SJOGRENS SYNDROME-CAUSED XEROSTOMIA AND XEROPHTHALMIA. ABSTRACT Sjogrens syndrome is a systemic autoimmune disease caused by secretory gland dysfunction, which is reflected by the dryness of mouth,eyes,nose,pharynx,larynx and vagina’s main mucosal surfaces. Since lacrimal and salivary glands are the mainly influenced glands.Xerostomia and xerophthalmia are the key clinical manifestations of Sjogrens syndrome. Until now, the main western clinical treatment of this disease is to increase exocrine gland secretion and regional lubrication. While Chinese medicine adopts Chinese herbs to make internal and external treatment, trying to promote the secretion of saliva or body fluid and nourish orifices. This paper provides an overview of the research develo