复杂对指与功能性电刺激下正常与受损脊髓的功能核磁共振研究-病理学与病理生理学专业论文.docx

汕头大学医学院博士学位论文 汕头大学医学院博士学位论文 PAGE PAGE 10 符合。fMRI信号变化波动于4.2％～13.2％之间。刺激与静息时相的信号变化幅度有显著 差异。部分激活信号出现于脊髓背侧，个别激活信号出现于对侧脊髓和脊髓周围脑脊液中。 4名完成实验的患者颈脊髓均出现稳定的fMRI信号，脊髓激活信号以刺激同侧脊髓背角感 觉神经元区域为主。刺激对侧脊髓的激活信号强度较弱，对侧脊髓的刺激信号主要位于背 角和中间带。 结论：利用单次激发快速自旋回波序列脊髓功能核磁共振技术能检测到复杂对指运动 和功能性电刺激时正常脊髓功能变化的信号，所得信号与相应的解剖位置相符合。使用 1.5T 医用核磁共振机和常规颈线圈对脊髓损伤患者的脊髓功能核磁共振成像能检测到受 损脊髓的神经信号，有助于评估脊髓功能状况。 关键词：功能核磁共振，脊髓，脊髓损伤，血管外质子信号 Functional MRI of the Healthy and Injured Human Spinal Cord with Complex Finger Tapping and Functional Electrical Stimulation Abstract Backgroud：Spinal fMRI is a reliable tool for assessing neuron status and localizing activity in the spinal cord. In healthy volunteers the method has proved capable of demonstrating spinal cord neuronal activity in response to different stimulations. Finger tapping is a well-established stimulation task for mapping neuronal function in the human brain. Electrical stimulation is widely used as a diagnostic method in spinal cord diseases and has a long history as a rehabilitation tool for restoring mobility after spinal cord injury. The present investigation is to determine if spinal cord neuronal activation while undergoing a complex finger tapping task and electrical stimulation can be observed by spinal fMRI with a SSFSE sequence. Standard assessment of the condition of the spinal cord after an injury, or when affected by disease, is limited to the information that can be revealed by external signs. Information about the full extent of the cord’s condition, and any changes as a result of clinical interventions, is becoming increasingly valuable as treating spinal cord injury (SCI) patients. The purpose of the work we are carrying out is to apply the noninvasive method of fMRI in the injured spinal cord. Purpose: Functional MR imaging of the human spinal cord was carried out on volunteers with complex finger tapping task and functional electrical stimulation, in order to detect image intensity changes arising from neuronal activity. Spinal fMRI was also