钙化退行性主动脉瓣病变与冠心病关系的研究-外科学(胸血管外科学)专业论文.docxVIP

— —1— 摘 要 钙化退行性主动脉瓣病变与冠心病关系的研究 研究生：刘大伟 指导老师：木拉提 副教授 摘 要 目的：通过超声心动图及冠状动脉造影的检查,探讨钙化退行性主动脉瓣病变患 者与冠心病的关系。方法：随机抽查在新疆医科大学一附院因胸痛拟诊为冠心病的 286 例住院患者,均经过超声心动图及冠状动脉造影术检查。根据超声心动图对钙化 退行性主动脉瓣情况的检查,将其分成钙化退行性主动脉瓣病变组(63 例)及无钙化退 行性主动脉瓣病变对照组(223 例) , 然后这 286 例住院患者，再根据冠状动脉造影的 检查,将其分成冠心病组(77 例)及无冠心病组(209 例)。 测定 286 例住院患者的性 别 血压级别 吸烟 年龄段 TG, TC, HDL-C and LDL-C 血糖等指标；卡方检验、t 检 验及方差分析上述指标的差异，用 logistics 回归方法分析上述因素对钙化退行性主动 脉瓣病变的影响，然后，再用 logistics 回归方法分析上述因素及钙化退行性主动脉瓣 病变对冠心病的影响。结果: 冠状动脉造影检查: 钙化退行性主动脉瓣病变组与对照 组比较有统计学差异(P0.05)。钙化退行性主动脉瓣病变组与对照组在年龄、高血压 史、及 LDL-C 有统计学差异(P0.01);而在性别糖尿病史 TG、TC、HDL-C 比较无统 计学差异(P0.05); 多因素 Logistic 回归分析发现, 钙化退行性主动脉瓣病变病变是 冠心病有价值的因素(P0.01),且预测力大于年龄和 TG;对于糖尿病和血压级别患者 而言, 钙化退行性主动脉瓣病变仍然是冠心病有价值的预测因子(P0.001)。结论：钙 化退行性主动脉瓣病变与冠心病有一定的相关性,成人主动脉瓣疾病有心绞痛症状行 手术治疗术前应常规行冠状动脉脉造影检查,无心绞痛症状的病人行此检查的年龄应 适当放宽。 关键词：主动脉瓣病；冠心病；冠状动脉造影； 超声心动图；钙化退行性主动脉瓣疾病 2 2 新疆医科大学医学硕士学位论文 The analysis of association between degenerative calcific aortic valve disease and coronary heart disease Postgraduate: LiuDawei Supervisor Prof: Mulati .Abudurehaman Abstract Objective: To explore the relationship between degenerative calcific aortic valved- isease (DCAVD) and coronary heart disease (CHD) by using echocardiography (ECG) and coronary angiography (CAG). Method: 286 patients with stethalgia ( age≥33 yearsold) were retrospectively reviewed. Each of them had undergone ECG and coronary angio- graphy. They were divided into two groups, DCAVD group and non- DCAVD group according to the result of ECG. They were also divided into two groups, CHD group and non CHD group, according to the result of coronary angiography (CAG). Age, gender,history of hypertension, diabetes, smoking, TG,TC,HDL-C and LDL-C were measured. ChiSquare test, T-test and ANOVA were used to analyze the different of those indexes between two groups .Analysis the relationships between DCAVD and those factors mentioned by multiple logistic analyses. And Analysis the relationships between CHD and those factors added DCAVD by Multiple logistic analyses.