干燥综合征患者口腔情况调查研究-口腔临床医学专业论文.docx

山西医科大学硕士学位论文 山西医科大学硕士学位论文 I I 干燥综合征患者口腔情况调查分析 摘 要 目的： 调查分析干燥综合征（Sjogren’s syndrome,SS ) 患者是否比正常人更易引起龋病、 牙周病、口腔粘膜病及其他口腔并发症，探讨SS患者唾液流率的变化与龋病的关系， 为SS患者诱发口腔症状的预防控制提供临床依据。 方法： 临床上对 61 例 SS 患者及与其年龄性别相匹配的 67 例无系统性疾病的健康体检 者，均进行全面系统的口腔检查并记录。分析 SS 病例组与健康对照组之间的牙周病、 龋病、口腔粘膜患病情况及其他口腔临床检查阳性指标的差异情况；并分析 SS 患者 唾液流率的变化与龋失补指数之间的关系。应用 SPSS20.0 软件进行统计学数据分析。 结果： 1.SS 组口腔粘膜病及其他口腔并发症的患病情况高于对照组，差异显著（P＜0.001）； 2.SS 组总体人群的患龋率高于对照组，差异显著（P＜0.001），龋均 X DMFT 高于对 照组，差异显著（P＜0.001）； 3.SS 组龋失补 DMFT 指数与唾液流率呈负相关，但统计学无显著性（P＞0.05）； 4.SS 组的牙周患病率与对照组无统计学差异（P＞0.05） 。 结论： 1.SS 患者较健康对照组更易累及口腔黏膜疾病，且容易出现其他口腔并发症； 2.SS 患者患龋病的风险更高，并且患龋的严重程度较健康对照组更加严重； 3.SS 患者唾液流率降低与龋失补指数的增高不存在线性相关关系，龋病的严重程度可 能是与病程等相关因素共同作用的结果； II II 4.SS 疾病本身原因可能与牙周病的促发没有明显关系。 关键词：干燥综合征；口腔粘膜疾病；龋病；牙周病；其他口腔并发症 PAGE PAGE III Investigation and analysis of oral condition in patients with Sjogrens syndrome Abstract Objective: This study is based on an investigation and analysis of oral symptoms between SS patients and normal control group.Analyze and describe whether SS cause oral symptoms and other oral complications. To provide clinical basis for the prevention. Methods: 61 SS patients and age, gender matched 67 health physical people without systemic disease were healthy,oral examination and record were conducted in two groups.All patients were examined clinically under artificial light and by use of plane mirrors and other instruments.And then compared the difference between SS patients and healthy people about dental caries,periodontal related disease and other complication.The relativity between salivary flow rate and decayed-missing-filled teeth (DMFT) value in patients with SS were analyzed.Statistical analysis of monitoring data was conducted by SPSS 20.0 software. Results: SS group oral mucosal diseases and other oral complications prevalence rate was higher than the control group (P 0.001); The caries prevalence rate of SS patients was observably higher than those in the control group (P0.001), and DMFT index was also significantly highe