高重复频率飞秒激光无损纳米化难溶药物的研究-光电子技术专业论文.docxVIP

ABSTRCT Femtosecond laser micromachining has been widely used in many fields , but the traditional use of femtosecond laser micromachining mostly generated by the low repetition rate femtosecond Ti-sapphire light source, thus limiting its processing efficiency and speed. By means of various nano method, Class II ( non- soluble drug but can be absorbed )drugs’ biological activity can be improved. And it means such drugs can be used in actual clinical application. Among all methods, femtosecond laser can produce stable and clean nano- drug particles. In this thesis, we use a high repetition rate (50MHz) femtosecond laser to process: 1, nanorization of insoluble drugs paclitaxel in aqueous, processing paclitaxel from micron particles into nanoscale, 500nm average. 2, nanorization of the insoluble drugs betamethasone dipropionate, from one hundred micrometers of betamethasone dipropionate into particles of 1-10 micron particles. The spectrum analysis after the experiment confirmed the use of high repetition rate femtosecond laser generated no new substances in the process and shown hardly any degradation. This thesis for the first time proved that high repetition rate femtosecond laser with moderate pulse energy have more advantages in nano-pharmaceutical field than conventional nanosecond lasers or high repetition rate femtosecond laser with low pulse energy , and for the first time introduce Non-thermal melting theory. Thesis is divided into the following sections: 1, Describes the previous research progress and the general theory of femtosecond laser processing of high repetition rate femtosecond laser processing, as well as drug nanonization common requirements methods, and the previous results of the water-based nano machining. 2, Introduce the basic theory and experimental procedures used in photonic crystalfiber laser, high performance liquid chromatography, scanning electron microscopy, Fourier transform infrared spectroscopy, Raman spectroscopy, mass spectrome