2016 精准医学：风湿免疫指南之后治疗路径.pptVIP

2、激素暴露时间与股骨头坏死的关系 Glucocorticoid exposure was associated with osteonecrosis regardless of how recent the drug use was: Within 1 to 90 days, OR 5.8 (95% CI 1.6 to 21.2) Between 180 and 365 days earlier, OR 8.9 (95% CI 2.5 to 32.5) More than 730 days earlier, OR 4.3 (95% CI 2 to 9) When the researchers conducted a separate analysis limited to remote users – patients whose exposure was more than a year before the index date – they found persistent high risks: Between 30 and 90 days, OR 9.3 (95% CI 2.5 to 34.9) Between 90 and 180 days, OR 4.1 (95% CI 0.4 to 47.9) More than 365 days, OR 165.4 (