L-谷氨酸的胃肠道保护作用机制及药物开发房凤玲丁劲松中南大学湘.PDFVIP

L-谷氨酸的胃肠道保护作用机制及药物开发 房凤玲, 丁劲松*1 （中南大学湘雅药学院，湖南长沙 410013 ） 摘要：L-谷氨酸是食物蛋白质的重要组成，在营养代谢、能量供应、免疫响应、氧化应激 及信号通路调节等过程中发挥重要作用。近期研究发现，谷氨酸可预防非甾体抗炎药（NSAIDs ） 引起的胃肠道损伤，并可促进损伤的修复；可抑制幽门螺杆菌的定植、抑制NH 引起的细胞凋 3 亡，在非甾体抗炎药与幽门螺杆菌致消化道损伤与溃疡治疗中具有潜在的应用价值。本文对谷 氨酸的代谢、生理作用，及其对非甾体抗炎药及幽门螺杆菌引起胃肠道损伤的保护机制进行了 综述，以期为谷氨酸用于降低NSAIDs损伤及抗幽门螺 菌致溃疡的相关药物研究开发提供参 考。 关键词：谷氨酸; 幽门螺杆菌; 非甾体抗炎药; 胃溃疡; 保护作用 Protective mechanisms of L-glutamate on gastrointestinal and drug development FANG Feng-ling, DING Jin-song* (Xiangya School of Pha rmaceutical Sciences, Central South University, Changsha 410013, China) Abstract: L-glutamate is an important component of protein. It has many physiological functions, such as nutrient metabolism, energy supply, immune response, oxidative stress, and signaling pathways regulation. Recent studies have found that glutamate can prevent gastrointestinal damage caused by non-steroidal anti-inflammatory drugs (NSAIDs) and promote the healing of the lesions. It can inhibit colonization of Helicobacter pylori and cells apoptosis caused by NH . Hence, it has potential value for protecting gastrointestinal damage caused by NSAIDs 3 and Helicobacter pylori . This article reviews the metabolism and physiological function of glutamate and its protective mechanisms of gastrointestinal injury caused by NSAIDs and Helicobacter pylori , expecting to give support to the reference for the study of drugs related to glutamate. Key words: glutamic acid; Helicobacter py lori; non-steroidal anti-inflammatory drugs; stomach ulcer; protection 收稿日期: 2016-10-19; 修回日期: 2016-12-08. 基