血清sHLA―G动态变化在先兆流产结局中的研究.docVIP

血清sHLA-G动态变化在先兆流产结局中的 研究 H的：通过定量测定正常妊娠者、先兆流产继续妊娠者及流 产者体内血清sHLA-G水平，探讨其动态变化与妊娠结局的关系。方法: 选取2015年7月至12月就诊于长沙市妇幼保健院并要求保胎的先兆 流产患者根据保胎结局分为继续妊娠组和流产组，同期在我院定期常 规产检的正常妊娠孕妇为对照组，采用ELISA法于妊娠第5-10周每周 一次定量检测50例正常妊娠孕妇及140例先兆流产并要求保胎治疗孕 妇体内血清sHLA-G变化值。结果：随着孕周的进展，三组血清sHLA-G 均呈下降趋势，但流产组血清sHLA-G基础值偏低，且下降速度较快， 对照组、继续妊娠组及流产组血清sllLA-G在孕5周时分别为(84.32 ±7. 02) U/ml、(82. 36±6. 65) U/ml、(52.77±5.23) U/ral,到孕 10 周吋则分别下降为(60. 47±5. 31) U/ml、(58. 71 土5. 02) U/ml、(9. 73 ±2. 82) U/ml,同一孕周水平，三组之间的sHLA-G水平差异均有统计 学意义(P0. 05)；对照组与继续妊娠组患者体内血清sHLA-G水平差 异无统计学意义(P〉0. 05),流产组与继续妊娠组患者体内血清sIILA-G 水平差异显著。结论：sHLA-G基础值偏低及降低速度过快可能会导致 原因不明性流产的发生。 ，供学习和研宄 使用， 和著作权归原 所有， 己 关键词：先兆流产；sIILA-G；结局预测 R714 A 1671-2064 (2017) 12-0188-03 Abstract: Objective: To investigate the relationship between scrum levels of sHLA~G and its According to the outcome of pregnancy, the patients were divided into two groups dynamic changes and pregnancy outcom through quantitative determination. Methods： patients with threatened abortion and tocolytic treatment in changsha maternal and child health care hospital from july 2015 to dcccmbcr as Pregnancy group and abortion group according to pregnancy outcome, normal pregnant women as control group. Quantitative detected the serum sHLA-G of 50 cases of normal pregnant women and 140 cases of threatened abortion that asked tocolytic therapy by enzyme linked immunosorbent assay (ELISA) . Results： With the development of gestational weeks, the serum sllLA-G levels of the three groups showed a downward trend, but the serum sHLA~G value was lower in abortion group, and the rate of decline was faster. At 5 weeks of gestation, The Control group, pregnancy group and abortion group serum sHLA-G were (84. 32+7. 02) U/ml，(82. 36 +6. 65) U/ml (52. 77+5. 23) respectively，when lOweeks of gestation, they decreased to (60. 47±5. 31) U/ml、(58. 71 ±5. 02) U/ml、(9. 73 ± 2.82 ) U/ml respectively. The levels of sllLA-G were statistically significant at the same gestational week between the three groups (P0. 05