Association of the BCRP C421A polymorphism with nonpapillary renal英文版本.pdf

Int. J. Cancer: 117, 431–434 (2005) 2005 Wiley-Liss, Inc. Association of the BCRP C421A polymorphism with nonpapillary renal cell carcinoma 1 1* 2 1 2 2 Yoshihito Korenaga , Katsusuke Naito , Naoko Okayama , Hiroshi Hirata , Yutaka Suehiro , Yuichiro Hamanaka , Hideyasu Matsuyama1 and Yuji Hinoda2 1 Department of Urology, Yamaguchi University School of Medicine, Yamaguchi, Japan 2Department of Clinical Laboratory Science, Yamaguchi University School of Medicine, Yamaguchi, Japan Breast cancer resistance protein (BCRP), the second member of cells and show higher expression in the small intestine, colon, the ATP-binding cassette membrane transporter family, has a sin- liver canaliculi, renal tubules, placenta and blood–brain barrier.10 gle nucleotide polymorphism, C421A (resulting in Q141K), that is This protein is also involved in the efflux of a variety of sub- of functional importance. Our aim was to explore the relationship stances, including anticancer compounds, fluorescent dyes and between this polymorphism of the BCRP gene and the risk of renal 10 cell carcinoma (RCC) development. For a case-control study, toxic compounds. SNPs of the BCRP gene have been reported DNA samples from 200 nonpapillary RCC patients and 200 in some ethnic populations,12 including Japanese,13,14 with fre- healthy control subjects were analyzed using the TaqMan techni- quent genotypes at G34A and C421A. C421A appears to be the que. The genotypic frequencies of the BCRP C421A polymorphism most functionally