高剂量调强适形放疗联合吉西他滨治疗局部晚期胰腺癌的临床观察肿瘤学专业论文.docxVIP

PAGE PAGE IV 高剂量调强适形放疗联合吉西他滨治疗局部晚期胰腺癌的临床观察 英文摘要 Clinical Observation of Intensity Modulated Radiationtherapy(IMRT) Dose Escalation With Concurrent Gemcitabine (GEM) in Patients With Locally Advanced Pancreatic Cancer Abstract Purpose：About 50-60% of pancreatic cancer diagnosed as locally advanced could not accepted curative resection, with the median survive time 6 to 10 months. Intensity modulated radiationtherapy(IMRT) is a new technique of radiotherapy. The objectives were to evaluate the acute adverse effect and efficacy of high-dose IMRT ( DT 60Gy/30Fractions/6weeks ) with concurrent gemcitabine (GEM) in Patients With local advanced pancreatic cancer . Methods and Materials：From January 2007 to May 2011, 39 cases with locally advanced pancreatic cancer confirmed by pathology or CT/MRI/PET-CT were enrolled in the study retrospectively.They were treated by high-dose IMRT with concurrent gemcitabine . IMRT dose escalation : 60Gy(2Gy/fraction). Gemcitabine 1000mg/m2， 30-minute infusion，day 1, day 8, day 22, day 29. After IMRT, beginning any time after week 7, up to 4 cycles of single-agent gemcitabine may be administered using the same schedule (day 1, 8 every 21 days). Results：1. All patients finished the concurrent chemoradiotherapy. The overall response rate（complete response rate〔CR〕+ partial response rate〔PR〕）was 38.5％ and local control rate（CR+PR+SD〔stable diease〕）was 92.3%. Median survival was 14.0 months (95% confidence interval〔CI〕12.3-15.7). 1-year and 2-year overall survival was , 27.1% respectively. 73.3% （22/30）of the patiens who sufferd from pain got relief. Karnofsky performance score(KPS) was improved in 25 (25/39,64.1%) cases. Life qualities of patients improved obviously without any treatment related death. The main toxicities observed in this therapy regimen included hematologic 英文摘要 高剂量调强适形放疗联合吉西他滨治疗局部晚期胰腺癌的临床观察 toxicities 79.5%（33/39）and gastrointestinal toxicities 76.9%（30/39）. The rate of severe to