餐后高血糖和祝福心血管危险因素.pptVIP

Post Prandial Hyperglycemia: A Significant Cardiovascular Risk Factor Treatable Precedent of Type 2 Diabetes Diagnostic Criteria for Type 2 DM Pathophysiology of type 2 DM Post Prandial Hyperglycemia (PPH) and diabetic complications Prevention of Type 2 DM The increasing global burden of diabetes Diagnosing glucose intolerance –criteria reflect a need for early intervention FPG and 2h-PG values identify different people with diabetes The Relative Contribution of FPG and Mealtime Glucose Spikes to 24-hour Glycemic Level A Comparison of Hba1c Levels Achieved in the Conventional Versus Intensive Groups of Major Trials UKPDS 10 yr-Cohort Data: Dissociation Between FPG HbA1C Duration of Daily Metabolic Conditions Intensive Treatment Policies The Funagata Cohort Population The Funagata Cohort Population Acarbose has a rapid and sustained effect on diabetes risk Chinese studies support the efficacy of acarbose in patients with IGT An emerging algorithm to manage IGT Development of evidence-based systems to identify those with IGT at most risk of diabetes Lifestyle intervention as first-line therapy for high-risk population Pharmacotherapy for those who are not able to attain stable glycaemia with lifestyle intervention Pharmacotherapy following lifestyle intervention failure is supported by the International Diabetes Federation IGT: impaired glucose tolerance Conclusions Management of the diabetes epidemic is an urgent global priority IGT is an appropriate target for intervention to prevent diabetes Acarbose has a proven record for safe, long-term management of postprandial hyperglycaemia Acarbose is proven to reduce the risk of diabetesand cardiovascular disease STOP-NIDDM results suggest that acarbose can reduce the burden that type 2 diabetes places on individuals and society IGT: impaired glucose tolerance, STOP-NIDDM: Study to Prevent Non-insulin Dependent Diabetes Mellitus Slide 34: Study design ? The Study to Prevent Non-insulin Dependent Diabetes