ctgf在ckd中的表达及其与临床病理的系-内科学(肾内科)专业毕业论文.docxVIP

兰州大学硕士学位论文 Expression of CTGF in CKD and the Correlation between CTGF and Clinical Pathology ABSTRACT Objective：To detect the expression of connective tissue growth factor(CTGF)in human renal biopsy and to study the correlation between CTGF and clinical pathological analysis of CKD． Methods：Ninety specimens were obtained by percutaneous renal biopsy from patients with various renal diseases．CTGF expression were detected by immunohistochemistry．We evaluated the expression and localization of CTGF,To investigate the associations of the CTGF and degrees of inflammation and fibrosis．To study the relationship of the expression of CTGF and other clinical、laboratory indices． Results：QThe expression of CTGF Was no or only a little in normal tissues．It Was much higher in CKD．@The expression of CTGF Was highly significant correlated with the extent fibrosis if,0．05)，．③The expression of CTGF in hypertensive groups(3．43±O．36)Was significantly increased compared晰廿l controls(1．30 4-0． 24)，and there were siguificant differences among the two groups(P0．05)．@The expression of CTGF in proteinuria groups(13．59／24h)Was significantly increased compared with controls(P0．05)．@The expression of CTGF in groups of high uric acid Was significantly increased compared with controls(P0．05)．@The expression of CTGF in hyperlipemia groups Was significantly increased compared、)l，ith controls(P 0．05)．⑦The expression of CTGF Was positive correlated with the 13 2一MG concentration．(r=0．85，P0．05)．It Was negatively correlated诹th Cer(r---O．36，P 0．05)． Conclusion：CTGF may involved in tubulointerstifial fibrosisa and renal tubular function．Many risk factors which Can induce renal diseases may up—regulate CTGF expression．CTGF Was correlated、析t11 clinic pathological manifestation and chronic degrees．Our study indicates that CTGF may play an important role in the development TI  兰州大学硕士学位论文 and progression of glomerular sclerosis and tubulointerstitial fibrosis in CKD． Key words：connective tissue growth facto