Construction of Phylogenetic Trees of SARS VirusSARS病毒的进化树的构建.pptVIP

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Construction of Phylogenetic Trees of SARS VirusSARS病毒的进化树的构建.ppt

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Construction of Phylogenetic Trees of SARS VirusSARS病毒的进化树的构建

Construction of Phylogenetic Trees of SARS Virus Kuo-Si Huang (黃國璽) SARS Severe Acute Respiratory Syndrome 嚴重急性呼吸道症候群 Total cases: 8422 Number of cases currently hospitalised: 64 Number of cases recovered: 7442 Number of deaths: 916 WHO -- Summary table of SARS cases by country, 1 November 2002 – 7 August 2003 /entity/csr/sars/country/en/country2003_08_15.pdf SARS Country Total Recovering Recovered Death China 5327 29 4949 349 (Hong Kong) 1755 7 1448 300 Taiwan 665 10 475 180 Canada 251 10 200 41 Singapore 238 0 205 33 WHO -- Summary table of SARS cases by country, 1 November 2002 – 7 August 2003 /entity/csr/sars/country/en/country2003_08_15.pdf SARS in Taiwan from CDC.TW Some Figures about SARS Vero E6 cells Inoculated with Oropharyngeal Specimens from Patients with SARS. Ultrastructural Characteristics of SARS-Associated Coronavirus Grown in Vero E6 Cells. Coronavirus 冠狀病毒 Coronavirus 冠狀病毒 SARS-CoV COronaVirus SARS – A New Coronavirus Estimated Maximum-Parsimony Tree Based on the Sequence Alignment of 405 Nucleotides of the Coronavirus Polymerase Gene Open Reading Frame 1b (Nucleotide Numbers 15173 to 15578 Based on Bovine Coronavirus Complete Genome Accession Number NC_003045) Comparing SARS Coronavirus with Other Human and Animal Coronaviruses. A Novel Coronavirus Associated with Svere Acute Respiratory Syndrome This article is dedicated to the memory of Carlo Urbani. T. G. Ksiazek, D. Erdman, C. S. Goldsmith, S. R. Zaki, …(Carlo Urbani, M.D. ) … et al., A novel coronavirus associated with severe acute respiratory syndrome, The New England Journal of Medicine, Vol. 348, pp.1953-1966, May, 2003. Phylogeny Phylogeny Phylogenetic tree Evolutionary tree Clarifying the coronaviruses relationships Clinical relationships of SARS patients Three major groups Distance, character and likelihood Phylogeny Distance-based phylogeny Fitch-Margolias method Neighbor-joining (NJ) method Unweighted pai