α硫辛酸联合丁咯地尔治疗糖尿病.docVIP

硫辛酸联合丁咯地尔治疗糖尿病 李彤寰仇春健俞晓娟 解放军第八一医院内分泌科江苏南京210000 目的：评价alpha;硫辛酸联合丁咯地尔治疗糖尿病周围神经病变的临床 疗效、安全性。方法：57例2型糖尿病并发周围神经病变（DPN）患者随机分 为两组。治疗组（n=30）静脉给予alpha;硫辛酸600mg联合丁咯地尔200mg, 1次八b连续14d;对照组（n=27）静脉给予alpha;硫辛酸600mg联合前列地 尔10mu;g, 1次/d,连续14d。分别于用药前、用药7d、14d进行多伦多临床 祌经病变评分（TCSS）和祌经病变主觉症状评分（TSS）,并记录其不良反应。结 果：两组在治疗7d时，TCSS、TSS评分均开始下降（P0 05）；治疗14天后, TCSS及TSS评分进一步显著降低（P0 01）；但治疗后两组间无显著性差异（P0 05）。治疗组有1例出现面色潮红；对照组有3例出现静脉炎而停止使用。结 论：alpha;硫辛酸联合丁咯地尔可有效改善2型糖尿病病人的周围神经病变, 且副反应少。 关键词 alpha;硫辛酸；丁咯地尔；前列地尔；糖尿病周围祌经病变 Efficavy and Safety of A Lipoic Acid Combined with Buflomedil in the treatment of Diabetic Peripheral Neuropathy Li Tonghuan, QIU Chunjian, YU Xiaojuan Abstract Objective To evaluate the efficavy and safety of a lipoic acid combined with buflomedil in the treatment of Diabetic Peripheral Neuropathy (DPN) . Methods： Sixth T2DM patients with DPN were dived into two groups. The treatment group(n=30) was intravenously injected with a lipoic acid 600mg/d and buflomedil 0 2g/d. The control group (n=27) was intravenously injected with a lipoic acid 600mg/d and alprostadil lOug/d. They were all treated once a day for 14 days. Befor and 7 and 14 days after the management，and total symptom score(TSS) were used to evaluate the nervous symptoms and record adverse recation. Results: The TCSS and TSS score 7 days after the management of the two groups reduced significantly after 7 days(both Plt;0 05). The TCSS and TSS score 14 days after the management of the two groups were significantly lower than that of the two groups 7 days (both Pl t; 0 01). But there were no signifant differences between two groups (Pgt;0 05). One patient of the treatment group felt flushed face 2 days after treatment，three patient of the control group was found phlebitics and stop treatment. Conclusion： A lipoic acid combined with alprostadil effectively improves the sensitive symptoms of DPN patients and is safe for most of the patients. ［Key words］ A Lipoic acid； Buflomedi1； Alprostadil； Diabetic peripheral neuropath