毕业论文苯氧甲基青霉素提取工艺研究.docVIP

摘 要 生产实际出发，以青霉素 V 及其提取工艺为研究对象，查阅了大量国内外发表的相关文献，利用现有实验及生产条件，对青霉素 V 的物性参数及其提取工艺过程进行了研究。 测定了在温度 25℃ 关键词： 苯氧甲基青霉素 青霉素 V 提取 沉淀 乙酸丁酯 Abstract This thesis focuses on the character parameters of pheoxymethylpenicillin and its extraction process referring to the related reference. Character parameters of saturated penicillin V water solution were mensurated at 25℃: pH=2.95, potency=844 u/ml,ionization constant K a=0.00421，pKa=2.38. Its distribution coefficient between the phases in the butyl acetate-water system was studied.Water was discovered to be an important complex solubilizer for penicillin V to dissolve in butyl acetate.And the water effect regulation and curve for penicillin V to dissolve in butyl acetate-water system were obtained.Tests of water percentage effect to the solubility of penicillin VK dissolved in butanol were carried out. Researches on the solubility of penicillin VK dissolved in water at normal temperature were also conducted. Keywords: henoxymethylpenicillin, penicillin V butyl acetate 目 录 TOC \o 1-3 \h \z \u HYPERLINK \l _Toc294271665 第1章 文献综述 PAGEREF _Toc294271665 \h 1 HYPERLINK \l _Toc294271666 1.1 青霉素研究概况 PAGEREF _Toc294271666 \h 1 HYPERLINK \l _Toc294271667 1.1.1 青霉素 V 的降解规律 PAGEREF _Toc294271667 \h 3 HYPERLINK \l _Toc294271668 1.1.2 青霉素 V 的溶解性质 PAGEREF _Toc294271668 \h 3 HYPERLINK \l _Toc294271669 1.2 影响青霉素 V 成品质量的杂质 PAGEREF _Toc294271669 \h 4 HYPERLINK \l _Toc294271670 1.3 青霉素 V 提取技术研究 PAGEREF _Toc294271670 \h 5 HYPERLINK \l _Toc294271671 1.3.1 溶剂萃取法 PAGEREF _Toc294271671 \h 5 HYPERLINK \l _Toc294271672 1.3.2 沉淀法[2] PAGEREF _Toc294271672 \h 8 HYPERLINK \l _Toc294271673 1.3.3 离子交换法和吸附法 PAGEREF _Toc294271673 \h 8 HYPERLINK \l _Toc294271674 1.3.4 青霉素提取新方法研究 PAGEREF _Toc294271674 \h 9 HYPERLINK \l _Toc294271675 第2章 青霉素 V 物性参数研究 PAGEREF _Toc294271675 \h 12 HYPERLINK \l _Toc294271676 2.1 材料及方法 PAGEREF _Toc294271676 \h 12 HYPERLINK \l _Toc294271677 2.1.1 试验材料 PAGEREF _Toc294271677 \h 12 HYPERLINK \l _Toc29427