万寿菊叶黄素一般药理学研究.PDF

2014年 2月第 21卷第 2期 中国中医药信息杂志 ·59· 万寿菊叶黄素一般药理学研究 翟建英,陈会丛,张广平,靳冉,朱晓光,杨海润,张思玉,蒋威,李晋生 北京中研同仁堂医药研发有限公司,中药复方新药开发国家工程研究中心,北京 100079 摘要：目的 观察万寿菊叶黄素对实验动物心血管系统、中枢神经系统和呼吸系统的影响。方法 采用十 二指肠给药观察万寿菊叶黄素对麻醉犬潮气量和呼吸频率、收缩压、舒张压、平均动脉压、心率、心电图的影 响；采用灌胃给药观察万寿菊叶黄素对小鼠自主活动行为、协调运动和戊巴比妥钠阈剂量和阈下剂量睡眠的影 响。结果 万寿菊叶黄素对麻醉犬的潮气量和呼吸频率、血压、心率、心电图均无明显影响,对小鼠的自主活 动行为、协调运动和戊巴比妥钠阈剂量和阈下剂量睡眠均无明显影响。结论 万寿菊叶黄素对实验动物的呼吸 系统、心血管系统及中枢神经系统均无明显影响,提示其不良反应小。 关键词：万寿菊叶黄素；心血管系统；呼吸系统；中枢神经系统；动物模型 DOI：10.3969/j.issn.1005-5304.2014.02.017 中图分类号：R285.5 文献标识码：A 文章编号：1005-5304(2014)02-0059-04 Study on General Pharmacology of Marigold Lutein ZHAI Jian-ying, CHEN Hui-cong, ZHANG Guang-ping, JIN Ran, ZHU Xiao-guang, YANG Hai-run, ZHANG Si-yu, JIANG Wei, LI Jin-sheng (Beijing Zhongyan Tongrentang Medicine RD Co. Ltd., National Engineering Research Center for RD of TCM Multi-ingredient Drugs, Beijing 100079, China) Abstract ：Objective To observe the effects of Marigold lutein on the cardiovascular system, the nervous system and the respiratory system of experimental animals. Methods The influence on blood pressure, heart rate, electrocardiogram, breathing flow and frequency in anesthetic dogs were observed after duodenum euonymus, and the impact on spontaneous activity, coordinated movement, and the sleep situation of threshold dose and sunthreshold dose pentobarbital sodium in mice were observed by intragastric administration of Marigold lutein. Results Marigold lutein had no side effects on breathing flow and frequency, blood pressure, heart rate, electrocardiogram in anesthetic dog, and had no obvious influence on spontaneous activity and coordinated movement in mice. Marigold lutein did not evidently change the number and the time of sleeping in mice. Conclusion Marigold lutein has no evident effects on respiratory system, card