前列腺非典型腺瘤样增生12例病理形态学观察.docVIP

PAGE PAGE 3 前列腺非典型腺瘤样增生12例病理形态学观察 赵红艳，叶明福，王亚丽，汤金梁，陈锐 （第三军医大学新桥医院病理科，重庆 400037） [摘要] 目的 探讨前列腺非典型腺瘤样增生（AAH）的病理形态学特征和鉴别诊断。方法 收集AAH标本12例，应用光镜、免疫组化EliVisionTMPlus二步法，选择34βE12、P63、P504S、PSA、PSAP抗体检测，观察其病理形态学特点和免疫组化表达特点。结果 12例前列腺非典型腺瘤样增生均来自于临床诊断为良性前列腺增生的前列腺手术切除标本，经进一步病理检查发现包含有AAH病灶， 12例腺泡均呈结节状增生，增生的腺泡排列紊乱、结构完整，基底细胞难以辨别，需要与高分化腺癌的腺泡鉴别；8例由大小基本一致的中小腺泡构成，4例增生的腺泡大小不均，11例腺泡呈低乳头状结构；12例中5例伴有前列腺萎缩后增生（PAH）。免疫组化显示，增生的腺泡边缘均有34?E12或p63阳性反应，P504S均显阴性；其中5例基底细胞基本完整，7例基底细胞断续存在。结论AAH是较少见的前列腺瘤样病变，在HE切片中，易误诊为前列腺高分化腺癌。基底细胞标记物34?E12、 p63和癌性上皮标记物P504S联合应用对 AAH的诊断具有实际应用价值。 [关键词] 前列腺非典型腺瘤样增生；病理学；免疫组化染色 Study on the basal cells of 11 postatrophic hyperplasia英文题目与中文不符。 英文题目与中文不符。 ZHAO Hong-yan,YE Ming-fu, WANG Ya-li (Department of Pathology, Xinqiao Hospital, TirdThird Military Medical University,Chongqin 400037,China Third Abstract: Purpose To investigate the pathological morphology features and differential diagnosis of atypical adenomatous hyperplasia（AAH）. Methods Twelve cases of AAH were investigated by hematoxylin-eosin and immunohistochemical stain（two-step Elivision? Plus method）to detect the expression of 34βE12、，P63、，P504S、，PSA and PSAP. The pathological morphology and immunohistochemical features of of 删除Aatypical adenomatous hyperplasia were studied. Results Twelve cases had been diagnosed as benign prostate hiplasia拼写错误 and excised by radical prostatectomies, which were rediagnosed as AAH later. In all cases acini were hyperplased？ nodularly　in a disarranged pattern　with intact structure and uncertain basal cells,which made them necessary to be distinguished from carcinoma. In this study, moderate or small acinis with almost same size were observed in 8 cases,and different size in the other 4 cases; and low papillary structure were obeserved in 11 of 12 cases, as well as postatrophic hyperplasia in 5 of 12 cases around the Atypical adenomatous hyperplasia. Throgh 拼写错误immunohistochemical stain of 34βE12, P63 and P504S , almost intact basal cells were observed in 5 cases and partl