老年男性骨质疏松患者血清胰岛素样生长因子,内皮素与骨钙素及骨转换生化指标的相关性研究.docVIP

老年男性骨质疏松患者血清胰岛素样生长因子、内皮素与骨钙素及骨转换生化指标的相关性研究 郭应龙 作者单位：山东临沂，山东医学高等专科学校附属医院，276004 通讯作者：郭应龙（1980~），男，主治医师，研究方向：脊柱骨病外科。E-mail:guoyinglong1980@163.com. 【摘要】目的：探讨老年男性骨质疏松患者血清胰岛素样生长因子、内皮素与骨钙素及骨转换生化指标水平的变化及相关性。方法：采用酶联免疫法（ELISA）检测70例老年男性骨质疏松组（OP）及50例正常老年男性对照组（NS）的血清胰岛素样生长因子（IGF-1）、内皮素（ET-1）、骨钙素（BGP）、抗酒石酸酸性磷酸酶-5b（TRACP-5b），采用美国NORLAND双能X线骨密度仪测定腰椎（L2-4）的骨密度。结果：与对照组比较，OP患者的血清IGF-1、BGP和腰椎BMD明显的降低（P0.05），而血清ET-1、TRACP-5b明显升高（P0.05）；老年男性血清IGF-1与BMD、BGP成明显的正相关（P0.05），而与ET-1、TRACP-5b成明显的负相关（P0.05），ET-1与IGF-1、BMD、BGP成明显的负相关（P0.05），而与TRACP-5b成明显的正相关（P0.05）结论：血清内皮素的升高，胰岛素样生长因子的降低在老年男性骨质疏松患者的发病机制中可能发挥重要的作用。 【关键词】骨质疏松；胰岛素样生长因子；内皮素；骨钙素 Correlation between insulin-like growth factor-1, endothelin-1,BGP,and bone turnover markers on osteoporosis in elderly men Guo Ying-long Departmengt of orthopedics,Affiliated Hospital of Shandong Medical College,,Linyi,Shandong,276004,China [Abstract] Objective：To investigate the correlation between insulin-like growth factor-1 (IGF-1), endothelin-1(ET-1),BGP,and bone turnover markers(BTMs) on osteoporosis in elderly men.Method：The OP of the 70 groups of the osteoporosis elderly men and the IGF-1、ET-1、BGP、TRACP-5b of the 50 normal group were measured by ELISA, BMD of the（L2-4）were measured by dual energy X-ray absorptiometr .Result:The levels of IGF-1、BGP and BMD of the OP group were significantly lower than the control group (p0.05),and the levels of ET-1,TRACP-5b were significantly higher (p0.05).the level of IGF-1 of the elderly men group was positively correlated with BGP and BMD (p0.05),and was negatively correlated with ET-1,TRACP-5b (p0.05).The level of ET-1was negatively correlated with IGF-1、BMD、BGP(p0.05).and was positively correlated with TRACP-5b (p0.05).Conclusion:the elvation of the serum endothelin and the reduction of the insulin-like growth factor play an important role in Pathogenesis of the osteoporosis in elderly men. [Key words] osteoporosis；insulin-like growth factor-1；endothelin-1；osteocalcin 骨质疏松（osteoporosis OP）是由诸多因素引起代谢变化而导致