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良性前列腺肥大急性尿瀦留特拉唑嗪与阿夫唑嗪治疗-SAGEJournals
Hong Kong Journal of Emergency Medicine
Terazosin versus alfuzosin in treatment of acute urinary retention in patients
with benign prostatic hypertrophy
HN Tang , CT Lui , KL Tsui , HT Fung
Obj ective: To compare the efficacy and adverse reactions of terazosin and alfuzosin in treatment of acute
urinary retention in patients with benign prostatic hypertrophy. Des ig n: Case control study. Setting :
Emergency department of a regional hospital in Hong Kong. Methods: Our study included all adult male
with age at least 18 years old presented with acute urinary retention, having residual urine volume greater
than or equal to 300 ml after urinary catheterisation and with a presumed diagnosis of benign prostatic
hypertrophy. Patients treated with terazosin from December 20 13 to February 20 14 were retrospectively
included while patients treated with alfuzosin from April to September 20 14 were prospectively included.
We compared the two groups on: trial without catheter (TWOC) rate, potential adverse effects including
drug-associated postural hypotension, haemodynamic changes and prolongation of corrected QT interval in
electrocardiogram. Cost effectiveness analysis was performed. Results: A total of 116 patients were included
with 59 and 57 patients in the terazosin and alfuzosin group respectively. Logistic regression showed that
residual urine volume (odds ratio [OR]=0.998, 95% confidence interval [CI]=0.996-0.999, p=0.008) and
presence of precipitating factors (OR=2.264, 95% CI= 1.045-5.793, p=0.045) were independent predictors
of successful TWOC. There was no significant difference in the TWOC rate for patients treated with alfuzosin
and terazosin. There was significantly more symptomatic postural hypotension in the terazosin group compared
with the alfuzosin group. The number need to treat with alfuzosin for terazosin to avoid
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