新型大豆苷元萘磺酸酯的合成.PDFVIP

安徽农业大学学报, 2018, 45(1): 145-148 Journal of Anhui Agricultural University [DOI] 10.13610/ki.1672-352x016 网络出版时间：2018/3/2 9:39:39 [URL] /kcms/detail/34.1162.S0939.032.html 新型大豆苷元萘磺酸酯的合成 1 1 1 2 彭 游 ，许冬民 ，徐菲菲 ，曲伟红 (1. 九江学院化学与环境工程学院，江西省生态化工工程技术研究中心，九江 332005 ；2. 九江学院基础医学院，九江 332005) 摘 要：为了提高大豆苷元抑制血管平滑肌细胞异常增殖活性，利用药动团变换原理对大豆苷元进行修饰，设 计合成了一系列新型大豆苷元萘磺酸酯衍生物，为进一步抑制血管平滑肌细胞活性实验提供样品。从时间、温度、 反应物配比、溶剂与催化剂配比、反应物与催化剂配比等 5 个方面优化了关键中间体 2 的合成工艺, 所有化合物的 结构均经 IR 、MS 、1H NMR 和元素分析予以确证。 关键词：大豆苷元；萘磺酸酯；合成 中图分类号：O629.9 文献标识码：A 文章编号：1672352X (2018)01014504 Design and synthesis of daidzein naphthalene sulfonic acid esters 1 1 1 2 PENG You , XU Dongming , XU Feifei , QU Weihong (1. Jiangxi Province Engineering Research Center of Ecological Chemical Industry, Department of Chemistry and Eenvironment Engineering, Jiujiang 332005; 2. Basic Medical College, Jiujiang University, Jiujiang 332005) Abstract: In order to improve the inhibitory activity of daidzein on the abnormal proliferation of vascular smooth muscle cells, we designed and synthesized a series of daidzein naphthalene sulfonic acid ester derivatives based on the principles of kinetophore transformation, and their structures were characterized by IR, MS, elemental 1 analysis and H NMR spectral data. The synthesis process of key intermediate 2 was optimized in five aspects of time, temperature, the ratio of reactants, the ratio of solvent to catalyst, and the ratio of reactant to catalyst. These compounds could be further employed to inhibit the abnormal proliferation of vascular smooth muscle cells. Key words