医学毕业慢性乙型病毒性肝炎血清铁及铁蛋白检测.docxVIP

XX大学 毕业论文 慢性乙型病毒性肝炎血清铁及铁蛋白检测 2014年6月25日 慢性乙型病毒性肝炎血清铁及铁蛋白检测 【关键词】 血清铁蛋白;血清铁；慢性乙型病毒性肝炎；肝纤维化指标 摘要：目的 探讨血清铁⑶)及铁蛋A(sf)在慢性乙型病毒性肝炎中的临 床意义。方法用放射免疫测定法测定SF、原子吸收光谱法测定SL结果慢 性HBV感染者多出现SI和SF升高，而且随着病情的加重而升高，在重型肝炎 组最为明显。SF、SI水平与HBV复制之间冇一定的相关性，随病毒复制增高而 增高,但无统计学意义。肝炎肝纤维化患者中,SF、SI随着ChildPugh分级(A、 B、C级)依次壇高，SF与肝纤维化指标LN冇相关性。SF升高的肝炎肝駛化患 者并发症的发生率及复发率较高，临床预后较差。结论SF、SI在-?定程度上 反映了病毒性肝炎的病变严重程度及其预后，可以作为预测肝炎预后的一项参考 指标。 关键词：血清铁蛋H；血清铁；慢性乙型病毒性肝炎；肝纤维化指标 Clinical meaning of scrum ferritin, iron in chronic hepatitic B ABSTRACT: Objective To investigate the clinical significance of serum ferritin level(SF), serum iron (SI) level in patients with chronic hepatitic B. Methods SF was measured by radioimmunoassay, serum iron was measured through atomic absorption spectrometry. Results Chronic HBV infcctors mostly had high level of SF and SI, with severity of illness state increasing, especially in the group of severe hepatitis. The levels of SF and SI correlated with HBV duplication to a certain extent and specifically SF and SI increased with the increase of virus duplication. However, it had no statistical significance. Among the sufferers of hepatocirrhosis, numerical values of SF and SI turned to increase with the rank of ChildPugh (A, B and C) and SF had the correlation with LN (the index of hepatic fibrosis). Patients of hepatocirrhosis with a high SF level had higher frequency of complications occurrence and reoccurrence, the clinical postcure effects were worse? Conclusion SF and SI can be reference index in forecasting the degree of disease state, hepatic fibrosis and clinical postcure? KEY WORDS: serum ferritin; serum iron; chronic hepatitis B; indicators of hepatic fibrosis 铁蛋白主要在肝脏合成，存在于肝脾和骨髓等脏器屮，是人体内储铁的标 志，可反映体内铁储存的水平。血清铁蛋0(serum ferritin, SF)量的多少是判断 体内缺铁述是铁负荷过量的指标，是检査体内铁缺乏最灵敏的指标。肝脏是铁贮 存和代谢的重耍脏器，因此肝病可以引起机体铁代谢的紊乱。近來的研究显示， 在HBV或HCV感染过程中，SF、血清铁(serum iron, SI)多明显升高，并且肝 组织存在铁的过量沉积。对于铁过负荷与慢性乙型肝炎及肝纤维化的关系，对 HBV感染患者临床预后的影响等，未见较大规模的临床研究。本研究拟在对2002 至2003年收住我院的106例慢性乙型肝炎患者分别测定SF、SI及肝功能、肝纤 维化血清学指标，并进行随访