2%和1%丙泊酚用于腹腔镜子宫肌瘤剔除术患者的药效学比较.PDF

2%和 1%丙泊酚用于腹腔镜子宫肌瘤剔除术患者的药效学比较  徐传华 1 ，钟桥生 2*(1.台州市立医院，浙江 台州 318000 ；2.厦门长庚医院，福建 厦门 361028) 摘要：目的 比较 2%与 1%丙泊酚的实际药效关系，减少丙泊酚麻醉患者脂质输入过多引起的相关不良反应。方法 择 期行腹腔镜子宫肌瘤剔除术患者 82 例，采用随机数字表法分为 1%丙泊酚组和 2% 丙泊酚组，每组 41 例；2 组丙泊酚诱 导靶控血浆浓度为 4 μg·mL1 ，术中靶控输注丙泊酚维持麻醉，根据脑电双频指数(bispectral index ，BIS)值调整丙泊酚的 靶控血浆浓度，使 BIS 值维持在 50 左右(45~55) ；记录意识开始消失所需时间、意识消失时丙泊酚用量、苏醒时间和丙 泊酚输注总量。结果 2% 丙泊酚组意识开始消失所需时间、意识消失时丙泊酚用量和丙泊酚输注总量1% 丙泊酚组，苏 醒时间1% 丙泊酚组，差异均有统计学意义(P0.05) ；2% 丙泊酚组脂剂的输入量为 1%丙泊酚组的 59%。结论 使用 2% 丙泊酚靶控输注麻醉，可减少丙泊酚麻醉患者的脂质输入量，减少脂质输入过多引起的相关不良反应；2% 丙泊酚的实际药效 约等于 1%丙泊酚的 1.7 倍。 关键词：丙泊酚；药效学；腹腔镜；子宫肌瘤 中图分类号：R969.4 文献标志码：B 文章编号：1007-7693(2018)08-1248-03 DOI: 10.13748/ki.issn1007-7693.2018.08.029 引用本文：徐传华, 钟桥生. 2%和 1%丙泊酚用于腹腔镜子宫肌瘤剔除术患者的药效学比较[J]. 中国现代应用药学, 2018, 35(8): 1248-1250. Comparison of Pharmacodynamics Between 2% and 1% Propofol in Patients with Laparoscopic Myomectomy 1 2* XU Chuanhua , ZHONG Qiaosheng (1.Taizhou Municipal Hospital, Taizhou 318000, China; 2.Xiamen Changgung Hospital, Xiamen 361028, China) ABSTRACT: OBJECTIVE To compare the pharmacodynamics between 2% and 1% propofol and reduce the related adverse reactions caused by excessive lipid input in propofol anesthesia. METHODS Eighty two patients undergoing elective laparoscopic myomectomy were randomly divided into 1% propofol group and 2% propofol group, with 41 cases in each group; Propofol was administrated with 4 μg·mL1 target plasma concentration during anesthesia induction and with adjusted target plasma concentration during operation according to the BIS value which was maintained at about 50 (45-55) in both group. The time of consciousness loss, propofol dosage at consciousness loss, wake-up time and total