药科大生物药剂学课件第一章 概述.pptVIP

to state a relationship between the factor of biology and dosage form and the pharmacologic effect of drug to provide scientific basis for evaluation of quality of the drug preparation and design and use of drug products rationally 1. Factors of dosage form Type of drug Physical and chemical properties of drug Dosage form and administration of drug The nature of excipients and additives and the dose of drug The technological process and operation conditions of preparation Incompatibility and interaction between drugs Type of drug i.e. ester, salt, complex, derivative and so on e.g. The solubility of sodium tolbutamide (甲磺丁脲钠)is better than that of tolbutamide. The pharmacologic effect is either. Physical and chemical properties  of drug i.e. diameter of particle, crystal form, solubility, dissolution rate and so on Dissolution is the process by which a chemical or drug becomes dissolved in a solvent Lots of facts have proved that the dissolution rate of tablets influences the absorption and clinical therapeutic effect. At the present, the pharmacopeia of China and many other countries all have requirement of dissolution rate for solid preparations such as tablets or capsules. e.g. convention tablets micronized tablets solid dispersion (pills) Griseofulvin (灰黄霉素) Dosage form and administration  of drug  i.e. tablets, capsules, injections, transdermal therapeutic system (TTS) and so on. e.g. the therapeutic effect of injections is faster than that of tablets. Because the former was absorbed rapidly to the blood systemic circulation. The nature of excipients and additives and the dose of drug e.g. The fillers of phenytoin sodium (苯妥英钠)capsules, calcium sulphate or lactose The technological process and operation conditions of preparation e.g. Preparatio