2017年美国皮肤病学会《皮肤鳞状细胞癌的管理指南》解读.pdf

中国循证医学杂志 2018年4月第18卷第4期 • 289 •   ·指南解读· 2017年美国皮肤病学会《皮肤鳞状细胞癌的 管理指南》解读 朱路得，王佩茹，张国龙，王秀丽 上海市皮肤病医院光医学治疗科，同济大学医学院（上海  200443 ） 【摘要】   皮肤鳞状细胞癌（cutaneous squamous cell carcinoma ，cSCC ）是人类第二大常见的皮肤肿瘤。近年 来，其发病率在全球范围内呈逐年递增趋势。大多数 cSCC 经常规治疗可治愈，但晚期 cSCC 进展快，严重影响患 者的生活质量，甚至导致死亡。2017 年，美国皮肤病学会（American Academy of Dermatology ，AAD ）基于大量循 证医学证据制定了最新版的 cSCC 管理指南，包括 cSCC 活检技术、组织病理学评估、临床分级分期、手术和非手 术治疗、随访、复发的预防以及晚期 cSCC 管理。本文旨在对该指南进行简要介绍和解读。 【关键词】  皮肤鳞状细胞癌；管理；美国皮肤病学会；指南；解读 The interpretation of AAD guidelines for the management of cutaneous squamous cell carcinoma ZHU Lude, WANG Peiru, ZHANG Guolong, WANG Xiuli Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, 200443, P.R.China Corresponding author: WANG Xiuli, Email: wangxiuli_1400023@tongji.edu.cn 【Abstract 】 Cutaneous squamous cell carcinoma (cSCC) is the second most common human skin tumor. In recent years, the incidence of cSCC is increasing annually. Although most cSCC is curable after basic treatment, the advanced cSCC progresses rapidly and poses a significant risk for the impact on quality of life and death. In 2017, the latest version of cSCC management guideline was developed by the American Academy of Dermatology (AAD) based on extensive evidence-based medical evidence, including cSCC biopsy techniques, histopathological assessment, clinical staging and grading, surgical and nonsurgical treatment, follow-up, recurrence prevention, and management of the advanced cSCC. The purpose of this article is to briefly introduce and interpretate this guideline. 【Key words 】 Cutaneous squamous cell carcinoma; Management; American Academy of Dermatology; Guideline; Interpretation 2017 年，美国皮肤病学会（American Academy